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63/100

✓ Peer-reviewed alzhub usefulness score 63 out of 100. Long-term cohort studies

Topic: Risk, prevention and care in population studies

Background and objectives The association between vascular risk factors and dementia varies with age, making generalizability of dementia risk prediction rules to individuals of different ages challenging. We determined the most important vascular risk factors for inclusion in age-specific dementia risk scores. Methods Framingham Heart Study Original and Offspring cohort participants with available data on the Framingham Stroke Risk Profile (FSRP) at midlife (age 55; n = 4,899, 57% women), late life (ages 65 or 70), or later life (ages 75 or 80 [n = 2,386, 62% women]) were followed for 10-year incident dementia risk from ages 65, 70, 75, and 80.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

McGrath, E. R., Beiser, A. S., O'Donnell, A., Himali, J. J., Pase, M. P., Satizabal, C. L., et al. (2022). Determining Vascular Risk Factors for Dementia and Dementia Risk Prediction Across Mid- to Later Life: The Framingham Heart Study. Neurology. https://doi.org/10.1212/wnl.0000000000200521

Vancouver

McGrath ER, Beiser AS, O'Donnell A, Himali JJ, Pase MP, Satizabal CL, et al. Determining Vascular Risk Factors for Dementia and Dementia Risk Prediction Across Mid- to Later Life: The Framingham Heart Study. Neurology. 2022. doi:10.1212/wnl.0000000000200521. PMID: 35584926.

BibTeX

@article{mcgrath2022-35584926,
  author  = {McGrath, E. R. and Beiser, A. S. and O'Donnell, A. and Himali, J. J. and Pase, M. P. and Satizabal, C. L. and Seshadri, S.},
  title   = {{Determining Vascular Risk Factors for Dementia and Dementia Risk Prediction Across Mid- to Later Life: The Framingham Heart Study}},
  journal = {Neurology},
  year    = {2022},
  doi     = {10.1212/wnl.0000000000200521},
  pmid    = {35584926},
  url     = {https://doi.org/10.1212/wnl.0000000000200521}
}

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Key findings

We determined the most important vascular risk factors for inclusion in age-specific dementia risk scores.
Methods Framingham Heart Study Original and Offspring cohort participants with available data on the Framingham Stroke Risk Profile (FSRP) at midlife (age 55; n = 4,899, 57% women), late life (ages 65 or 70), or later life (ages 75 or 80 [n = 2,386, 62% women]) were followed for 10-year incident dementia risk from ages 65, 70, 75, and 80.
Results Age- and sex-adjusted midlife risk factors associated with 10-year risk of dementia from age 65 included FSRP (hazard ratio [HR] 1.16, 95% CI 1.06-1.26, per 1 SD increment in log-transformed score), diabetes mellitus (DM; HR 4.31, 95% CI 1.97-9.43), and systolic blood pressure (SBP; HR 1.12, 95% CI 1.02-1.24, per 10 mm Hg increment).
Late-life risk factors associated with 10-year incident dementia from ages 65 or 70 included FSRP (age 65 only: HR 1.06, 95% CI 1.02-1.10), antihypertensive use (age 65 reported: HR 1.66, 95% CI 1.12-2.46), DM (age 65 reported: HR 1.96, 95% CI 1.09-3.52), atrial fibrillation (age 65 reported: HR 2.30, 95% CI 1.00-5.27), nonstroke cardiovascular disease (nsCVD; age 65 reported: HR 1.95, 95% CI 1.24-3.07), and stroke (age 70 only: HR 3.61, 95% CI 2.21-5.92).

Why it matters

This study used Framingham Heart Study participants to determine which vascular risk factors are most important for age-specific dementia risk scores across mid- to later life. It is observational, so it cannot show that treating these vascular risk factors would prevent dementia.

Study details

Participants4,899
Effect sizeHR 4.31; HR 1.12; HR 1.06
Evidence strengthModerate

How this study scored 63/100

Published in a leading specialty journal. Scored zero for study design and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (Neurology)
Journal's citation record	4 / 4	Neurology: journal h-index 525 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2022 — within 6 year(s) of the newest study here
Sample size	3 / 4	4,899 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 61 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	10.2 citations a year over 6 year(s) since 2022
Impact for its field and year	3 / 6	Cited 7.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 6 other studies in this library
Still being cited	2 / 4	Cited 41 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Sudha S. Seshadri: h-index 148 (OpenAlex, whole career)
Institution's track record	3 / 3	Harvard University: institution h-index 3,235 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 5 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 35584926)
Free to read	0 / 2	Behind a paywall — scores zero
Total	63 / 100	—

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