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Association of Multimorbidity, Disease Clusters, and Modification by Genetic Factors With Risk of Dementia
Calvin CM, Conroy MC, Moore SF, Kuzma E, Littlejohns TJ.. JAMA network open, 2022-09-01
Topic: Risk, prevention and care in population studies
Importance Individual conditions have been identified as risk factors for dementia; however, it is important to consider the role of multimorbidity, as conditions often co-occur. Objective To investigate whether multimorbidity is associated with incident dementia and whether associations vary by different clusters of disease and genetic risk for dementia. Design, setting, and participants This population-based prospective cohort study used data from the UK Biobank cohort, with baseline data collected between 2006 and 2010 and with up to 15 years of follow-up.
Key findings
- Objective To investigate whether multimorbidity is associated with incident dementia and whether associations vary by different clusters of disease and genetic risk for dementia.
- Design, setting, and participants This population-based prospective cohort study used data from the UK Biobank cohort, with baseline data collected between 2006 and 2010 and with up to 15 years of follow-up.
- Participants included women and men without dementia and aged at least 60 years at baseline.
- Medical conditions were captured as part of nurse-led verbal interviews conducted at baseline assessment centers.
Why it matters
Many older adults live with several health conditions at once, and this UK Biobank study asked whether having multiple conditions, and which combinations of them, is linked to later dementia, and whether a person's genetic risk changes that link. It followed women and men aged 60 or older who did not have dementia when they enrolled in 2006–2010, for up to 15 years, using conditions they reported in nurse-led interviews. It is an observational study: it can show associations, not cause and effect, and it does not test any treatment or prevention.
Study details
- Study designcohort study
- Participants960
- Effect size52.7%; 43.1%; 3.0%
- Evidence strengthModerate
How this study scored 67/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA network open) |
| Journal's citation record | 2 / 4 | JAMA Network Open: journal h-index 235 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 960 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 86 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.3 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 4 / 6 | Cited 9.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 13 other studies in this library |
| Still being cited | 3 / 4 | Cited 77 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Thomas J. Littlejohns: h-index 33 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Oxford: institution h-index 2,205 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36125811) |
| Free to read | 2 / 2 | Free to read |
| Total | 67 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1001/jamanetworkopen.2022.32124
- PubMed: 36125811
- Original source →
- Free full text: JAMA Network Open →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Calvin, C. M., Conroy, M. C., Moore, S. F., Kuzma, E., & Littlejohns, T. J. (2022). Association of Multimorbidity, Disease Clusters, and Modification by Genetic Factors With Risk of Dementia. JAMA network open. https://doi.org/10.1001/jamanetworkopen.2022.32124
Vancouver
Calvin CM, Conroy MC, Moore SF, Kuzma E, Littlejohns TJ. Association of Multimorbidity, Disease Clusters, and Modification by Genetic Factors With Risk of Dementia. JAMA network open. 2022. doi:10.1001/jamanetworkopen.2022.32124. PMID: 36125811.
BibTeX
@article{calvin2022-36125811,
author = {Calvin, C. M. and Conroy, M. C. and Moore, S. F. and Kuzma, E. and Littlejohns, T. J.},
title = {{Association of Multimorbidity, Disease Clusters, and Modification by Genetic Factors With Risk of Dementia}},
journal = {JAMA network open},
year = {2022},
doi = {10.1001/jamanetworkopen.2022.32124},
pmid = {36125811},
url = {https://doi.org/10.1001/jamanetworkopen.2022.32124}
}
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