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Evaluation of blood-based, extracellular vesicles as biomarkers for aging-related TDP-43 pathology
Charisse N Winston, Sonal Sukreet, Haley Lynch, Virginia M-Y Lee, Donna M Wilcock, Peter T Nelson, Robert A Rissman. Alzheimer's & dementia (Amsterdam, Netherlands), 2022-12-15
Topic: Plasma and spinal-fluid biomarkers
TDP-43 was significantly elevated in plasma ADEVs derived from autopsy confirmed LATE-NC subjects, with or without comorbid AD pathology. Measurable levels of TDP-43 were also detected in EV-depleted plasma; however, TDP-43 levels were not significantly different between persons with and without eventual autopsy confirmed LATE-NC. No correlation was observed between EV TDP-43 levels with cognition-based variables, sex, and APOE carrier status. Blood-based EVs, specifically measuring TDP-43 accumulation in ADEVs, may serve as a potential diagnostic tool to rapidly identify subjects who are currently living with LATE-NC.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Winston, C. N., Sukreet, S., Lynch, H., Lee, V. M.-Y., Wilcock, D. M., Nelson, P. T., et al. (2022). Evaluation of blood-based, extracellular vesicles as biomarkers for aging-related TDP-43 pathology. Alzheimer's & dementia (Amsterdam, Netherlands). https://doi.org/10.1002/dad2.12365
Vancouver
Winston CN, Sukreet S, Lynch H, Lee VM.-Y, Wilcock DM, Nelson PT, et al. Evaluation of blood-based, extracellular vesicles as biomarkers for aging-related TDP-43 pathology. Alzheimer's & dementia (Amsterdam, Netherlands). 2022. doi:10.1002/dad2.12365. PMID: 36540894.
BibTeX
@article{winston2022-36540894,
author = {Winston, Charisse N and Sukreet, Sonal and Lynch, Haley and Lee, Virginia M-Y and Wilcock, Donna M and Nelson, Peter T and Rissman, Robert A},
title = {{Evaluation of blood-based, extracellular vesicles as biomarkers for aging-related TDP-43 pathology}},
journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
year = {2022},
doi = {10.1002/dad2.12365},
pmid = {36540894},
url = {https://doi.org/10.1002/dad2.12365}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- TDP-43 was significantly elevated in plasma ADEVs derived from autopsy confirmed LATE-NC subjects, with or without comorbid AD pathology.
- Measurable levels of TDP-43 were also detected in EV-depleted plasma; however, TDP-43 levels were not significantly different between persons with and without eventual autopsy confirmed LATE-NC.
- No correlation was observed between EV TDP-43 levels with cognition-based variables, sex, and APOE carrier status.
- Blood-based EVs, specifically measuring TDP-43 accumulation in ADEVs, may serve as a potential diagnostic tool to rapidly identify subjects who are currently living with LATE-NC.
Study details
- Participants22
- Evidence strengthModerate
How this study scored 55/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 31 of the 56 points we could judge it on, which is 55 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia (Amsterdam, Netherlands)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 22 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36540894) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 31 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 31 of the 56 points we could judge it on is 55 out of 100. |
| Total | 55 / 100 | — |
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