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Baseline Statin Exposure and Incident Acute Myocardial Infarction in Adults Aged >=75 Years Without Prior Cardiovascular Disease: A Population-Based Cohort Study
Cardenas-Valladolid, J.; Alonso-del Cura, O.; Beneito-Dura, M.; Somolinos-Simon, F. J.; Mostaza, J. M.; La Hoz, C.; San Andres-Rebollo, F. J.; Vich-Perez et al.. medRxiv (preprint), 2026-08-25
Topic: Risk, prevention and care in population studies
In the fully adjusted Cox model, baseline statin exposure was associated with a lower risk of incident AMI (HR, 0.805; 95% CI, 0.731-0.887). In the full-cohort Fine-Gray model accounting for competing mortality, baseline statin exposure remained associated with a lower cumulative incidence of AMI (sHR, 0.823; 95% CI, 0.748-0.905). ConclusionsIn this large population-based cohort of adults aged [≥]75 years without prior cardiovascular disease, baseline statin exposure was associated with a lower incidence of AMI across several analytical approaches.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Cardenas-Valladolid, J., Alonso-del Cura, O., Beneito-Dura, M., Somolinos-Simon, F. J., Mostaza, J. M., La Hoz, C., et al. (2026). Baseline Statin Exposure and Incident Acute Myocardial Infarction in Adults Aged >=75 Years Without Prior Cardiovascular Disease: A Population-Based Cohort Study. medRxiv (preprint). https://doi.org/10.64898/2026.08.21.26361002
Vancouver
Cardenas-Valladolid J, Alonso-del Cura O, Beneito-Dura M, Somolinos-Simon FJ, Mostaza JM, La Hoz C, et al. Baseline Statin Exposure and Incident Acute Myocardial Infarction in Adults Aged >=75 Years Without Prior Cardiovascular Disease: A Population-Based Cohort Study. medRxiv (preprint). 2026. doi:10.64898/2026.08.21.26361002.
BibTeX
@article{cardenasvalladolid2026-84b9cd8f,
author = {Cardenas-Valladolid, J. and Alonso-del Cura, O. and Beneito-Dura, M. and Somolinos-Simon, F. J. and Mostaza, J. M. and La Hoz, C. and San Andres-Rebollo, F. J. and Vich-Perez and others},
title = {{Baseline Statin Exposure and Incident Acute Myocardial Infarction in Adults Aged >=75 Years Without Prior Cardiovascular Disease: A Population-Based Cohort Study}},
journal = {medRxiv (preprint)},
year = {2026},
doi = {10.64898/2026.08.21.26361002},
url = {https://doi.org/10.64898/2026.08.21.26361002}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- In the fully adjusted Cox model, baseline statin exposure was associated with a lower risk of incident AMI (HR, 0.805; 95% CI, 0.731-0.887).
- In the full-cohort Fine-Gray model accounting for competing mortality, baseline statin exposure remained associated with a lower cumulative incidence of AMI (sHR, 0.823; 95% CI, 0.748-0.905).
- ConclusionsIn this large population-based cohort of adults aged [≥]75 years without prior cardiovascular disease, baseline statin exposure was associated with a lower incidence of AMI across several analytical approaches.
Why it matters
This cohort study found that baseline statin exposure was associated with a lower incidence of acute myocardial infarction in adults aged 75 and older without prior cardiovascular disease. It concerns heart attack risk, not Alzheimer's disease treatment, cure or prevention.
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Study details
- Study designcohort study
- Participants174,014
- Effect size18.8%; 1.63%; 1.93%
- Evidence strengthHigh
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 41 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for randomised / blinded because the record does not state it. We have no data on impact for its field and year, so that was left out: it earned 39 of the 94 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (medRxiv (preprint)) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 4 / 4 | 174,014 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Miguel Ángel Salinero-Fort: h-index 26 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Hospital La Paz Institute for Health Research: institution h-index 226 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 1 country |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Points | 39 / 94 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 39 of the 94 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | Capped to 16 because this is not a peer-reviewed article. |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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