The Joint Effects of Life’s Essential 8 and Genetics on Mild Cognitive Impairment and Dementia Risk in People With Diabetes: Findings From the UK Biobank and All of Us
Xiu Wu, Yuanhao Zu, You Lu, Yue Zhao, David R. Crosslin, Vivian Andrew Fonseca, Demetrius Maraganore, Yilin Yoshida. Diabetes Care, 2026-08-27
Topic: Risk, prevention and care in population studies
Over 15 years of follow-up (UKB), moderate or high CVH versus low CVH was associated with a lower risk of MCI (hazard ratio 0.82 [95% CI 0.71, 0.95], P < 0.05) but not with risk of all-cause dementia (0.97 [0.84, 1.11], P = 0.63). In participants at high genetic risk (high PRS), moderate or high CVH was associated with a lower risk of MCI (0.78 [0.62, 0.98], P for additive interaction < 0.05). AoU results were consistent. Better CVH was significantly associated with a lower risk of MCI in people with diabetes, accounting for genetic risk. The association between CVH and MCI and dementia was stronger among individuals with low or moderate genetic risk and appeared attenuated among those with high genetic risk.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Wu, X., Zu, Y., Lu, Y., Zhao, Y., Crosslin, D. R., Fonseca, V. A., et al. (2026). The Joint Effects of Life’s Essential 8 and Genetics on Mild Cognitive Impairment and Dementia Risk in People With Diabetes: Findings From the UK Biobank and All of Us. Diabetes Care. https://doi.org/10.2337/dc25-3126
Vancouver
Wu X, Zu Y, Lu Y, Zhao Y, Crosslin DR, Fonseca VA, et al. The Joint Effects of Life’s Essential 8 and Genetics on Mild Cognitive Impairment and Dementia Risk in People With Diabetes: Findings From the UK Biobank and All of Us. Diabetes Care. 2026. doi:10.2337/dc25-3126. PMID: 42658064.
BibTeX
@article{wu2026-42658064,
author = {Wu, Xiu and Zu, Yuanhao and Lu, You and Zhao, Yue and Crosslin, David R. and Fonseca, Vivian Andrew and Maraganore, Demetrius and Yoshida, Yilin},
title = {{The Joint Effects of Life’s Essential 8 and Genetics on Mild Cognitive Impairment and Dementia Risk in People With Diabetes: Findings From the UK Biobank and All of Us}},
journal = {Diabetes Care},
year = {2026},
doi = {10.2337/dc25-3126},
pmid = {42658064},
url = {https://doi.org/10.2337/dc25-3126}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Over 15 years of follow-up (UKB), moderate or high CVH versus low CVH was associated with a lower risk of MCI (hazard ratio 0.82 [95% CI 0.71, 0.95], P < 0.05) but not with risk of all-cause dementia (0.97 [0.84, 1.11], P = 0.63).
- In participants at high genetic risk (high PRS), moderate or high CVH was associated with a lower risk of MCI (0.78 [0.62, 0.98], P for additive interaction < 0.05).
- Better CVH was significantly associated with a lower risk of MCI in people with diabetes, accounting for genetic risk.
- The association between CVH and MCI and dementia was stronger among individuals with low or moderate genetic risk and appeared attenuated among those with high genetic risk.
Why it matters
In people with diabetes, this study found that better cardiovascular health was associated with a lower risk of mild cognitive impairment but not with risk of all-cause dementia. The association was stronger among those with low or moderate genetic risk and appeared attenuated among those with high genetic risk.
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Study details
- Participants41,374
- Evidence strengthLow
How this study scored 42/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Diabetes Care) |
| Journal's citation record | 4 / 4 | Diabetes Care: journal h-index 509 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 4 / 4 | 41,374 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Yilin Yoshida: h-index 16 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Tulane University: institution h-index 735 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 42658064) |
| Free to read | 2 / 2 | Free to read |
| Total | 42 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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