Comparison of phenomic profiles in the… | 2024

This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

64/100

✓ Peer-reviewed alzhub usefulness score 64 out of 100. Long-term cohort studies

Topic: Risk, prevention and care in population studies

Plain-language summary

Importance Knowledge gained from cohort studies has dramatically advanced both public and precision health. The All of Us Research Program seeks to enroll 1 million diverse participants who share multiple sources of data, providing unique opportunities for research. It is important to understand the phenomic profiles of its participants to conduct research in this cohort.

What this study adds

Evidence grade: Moderate

This is a follow-up (cohort) study of 254 participants. This study compared the characteristics of participants in the All of Us Research Program with the US general population and the UK Biobank. Reported effect size: 80.9%.

Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Zeng, C., Schlueter, D. J., Tran, T. C., Babbar, A., Cassini, T., Bastarache, L. A., et al. (2024). Comparison of phenomic profiles in the All of Us Research Program against the US general population and the UK Biobank. Journal of the American Medical Informatics Association : JAMIA. https://doi.org/10.1093/jamia/ocad260

Vancouver

Zeng C, Schlueter DJ, Tran TC, Babbar A, Cassini T, Bastarache LA, et al. Comparison of phenomic profiles in the All of Us Research Program against the US general population and the UK Biobank. Journal of the American Medical Informatics Association : JAMIA. 2024. doi:10.1093/jamia/ocad260. PMID: 38263490.

BibTeX

@article{zeng2024-38263490,
  author  = {Zeng, C. and Schlueter, D. J. and Tran, T. C. and Babbar, A. and Cassini, T. and Bastarache, L. A. and Denny, J. C.},
  title   = {{Comparison of phenomic profiles in the All of Us Research Program against the US general population and the UK Biobank}},
  journal = {Journal of the American Medical Informatics Association : JAMIA},
  year    = {2024},
  doi     = {10.1093/jamia/ocad260},
  pmid    = {38263490},
  url     = {https://doi.org/10.1093/jamia/ocad260}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

How to read this study

Design: this is a follow-up (cohort) study. People are observed over time and not assigned to anything, so an association can reflect other differences between groups. Look at how long follow-up lasted, how many dropped out, and whether the authors adjusted for age, education and other health conditions.
Size: the record lists 254 participants. Ask whether that is enough for the question, and who they were.
Effect: the record reports “80.9%”. A statistically significant result can still be small in daily life.

What the evidence grade means here

This page is graded moderate. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Moderate means the abstract mentions a cohort, case-control or longitudinal design. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

New to reading papers? Six questions to ask of any Alzheimer’s study · how we score.

Key findings

The All of Us Research Program seeks to enroll 1 million diverse participants who share multiple sources of data, providing unique opportunities for research.
It is important to understand the phenomic profiles of its participants to conduct research in this cohort.
Objectives More than 280 000 participants have shared their electronic health records (EHRs) in the All of Us Research Program.
We aim to understand the phenomic profiles of this cohort through comparisons with those in the US general population and a well-established nation-wide cohort, UK Biobank, and to test whether association results of selected commonly studied diseases in the All of Us cohort were comparable to those in UK Biobank.

Why it matters

This study compared the characteristics of participants in the All of Us Research Program with the US general population and the UK Biobank. It aims to help researchers understand this cohort for future research, but does not itself test any treatment, cure, or prevention for Alzheimer's disease.

Study details

Study designcohort study
Participants254
Effect size80.9%
Evidence strengthModerate

How this study scored 64/100

Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of the American Medical Informatics Association : JAMIA)
Journal's citation record	2 / 4	Journal of the American Medical Informatics Association: journal h-index 232 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2024 — within 3 year(s) of the newest study here
Sample size	2 / 4	254 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 44 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	11.0 citations a year over 4 year(s) since 2024
Impact for its field and year	4 / 6	Cited 10.8× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	2 / 4	Cited 44 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Joshua C. Denny: h-index 106 (OpenAlex, whole career)
Institution's track record	3 / 3	National Institutes of Health: institution h-index 2,723 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 6 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 38263490)
Free to read	0 / 2	Behind a paywall — scores zero
Total	64 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Studies in the library that share something with this one. The line above each title says what.

Studies this one cites

Referenced by this study and also in the alzhub library, so you can read them here.

Related studies in Long-term cohort studies from nearby years

Also in Long-term cohort studies

54 studies in the library are filed under Long-term cohort studies with no topic tag they share with another; these are this study's neighbours in a fixed tour of them. The Long-term cohort studies hub.

Similar studies

More on Long-term cohort studies

See all studies in Long-term cohort studies →