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Explaining the Variability of Alzheimer Disease Fluid Biomarker Concentrations in Memory Clinic Patients Without Dementia
Bouteloup V, Pellegrin I, Dubois B, Chene G, Planche V, Dufouil C, MEMENTO Study Group.. Neurology, 2024-03-25
Topic: Amyloid, tau and blood-test diagnosis
Results In total, 2,257 participants were included in the analysis (median age 71.7, 61.8% women, 55.2% with high educational levels). Discussion This comprehensive analysis demonstrated that the variance in AD blood biomarker concentrations was mainly explained by age, with minor contributions from cognition, brain atrophy, and genetics, conversely to CSF measures. These results challenge the use of blood biomarkers as isolated stand-alone biomarkers for AD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Bouteloup, V., Pellegrin, I., Dubois, B., Chene, G., Planche, V., Dufouil, C., et al. (2024). Explaining the Variability of Alzheimer Disease Fluid Biomarker Concentrations in Memory Clinic Patients Without Dementia. Neurology. https://doi.org/10.1212/wnl.0000000000209219
Vancouver
Bouteloup V, Pellegrin I, Dubois B, Chene G, Planche V, Dufouil C, et al. Explaining the Variability of Alzheimer Disease Fluid Biomarker Concentrations in Memory Clinic Patients Without Dementia. Neurology. 2024. doi:10.1212/wnl.0000000000209219. PMID: 38527237.
BibTeX
@article{bouteloup2024-38527237,
author = {Bouteloup, V. and Pellegrin, I. and Dubois, B. and Chene, G. and Planche, V. and Dufouil, C. and {MEMENTO Study Group}},
title = {{Explaining the Variability of Alzheimer Disease Fluid Biomarker Concentrations in Memory Clinic Patients Without Dementia}},
journal = {Neurology},
year = {2024},
doi = {10.1212/wnl.0000000000209219},
pmid = {38527237},
url = {https://doi.org/10.1212/wnl.0000000000209219}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Results In total, 2,257 participants were included in the analysis (median age 71.7, 61.8% women, 55.2% with high educational levels).
- Discussion This comprehensive analysis demonstrated that the variance in AD blood biomarker concentrations was mainly explained by age, with minor contributions from cognition, brain atrophy, and genetics, conversely to CSF measures.
- These results challenge the use of blood biomarkers as isolated stand-alone biomarkers for AD.
Why it matters
This analysis found that age explained most of the variation in Alzheimer's blood biomarker levels, with only minor contributions from cognition, brain atrophy, and genetics. The authors conclude that blood biomarkers should not be used as stand-alone tests, and the study does not address treatment, cure, or prevention.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Participants2,323
- Effect size61.8%; 55.2%; 13.7%
- Evidence strengthLow
How this study scored 58/100
Published in a leading specialty journal. Scored zero for study design and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 56 of the 96 points we could judge it on, which is 58 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 2,323 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 19 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.8 citations a year over 4 year(s) since 2024 |
| Impact for its field and year | 3 / 6 | Cited 5.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 2 / 4 | Cited 19 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 2 / 3 | Inserm: institution h-index 1,988 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38527237) |
| Free to read | 2 / 2 | Free to read |
| Points | 56 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 56 of the 96 points we could judge it on is 58 out of 100. |
| Total | 58 / 100 | — |
What each of these 20 components measures, and what this score is not →
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