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Central autonomic network dysfunction and plasma Alzheimer's disease biomarkers in older adults
Trevor Lohman, Arunima Kapoor, Allison C Engstrom, Fatemah Shenasa, John Paul M Alitin, Aimee Gaubert, Kathleen E Rodgers, David Bradford et al.. Alzheimer's research & therapy, 2024-06-08
Topic: Brain imaging, connectivity and assessment
All autonomic networks were positively associated with Aβ42/40 ratio and remained so after adjustment for age, sex, and APOE4 carrier status. Overall and parasympathetic networks were negatively associated with GFAP. The relationship between the parasympathetic CAN and GFAP was moderated by APOE4 carrier status, wherein APOE4 carriers with low parasympathetic CAN connectivity displayed the highest plasma GFAP concentrations (B = 910.00, P = .004). Sensorimotor connectivity was not associated with any plasma AD biomarkers, as expected. The present study findings suggest that CAN function is associated with plasma AD biomarker levels. Specifically, lower CAN functional connectivity is associated with decreased plasma Aβ42/40, indicative of cerebral amyloidosis, and increased plasma GFAP in APOE4 carriers at risk for AD. These findings could suggest higher order autonomic and parasympathetic dysfunction in very early-stage AD, which may have clinical implications.
Key findings
- All autonomic networks were positively associated with Aβ42/40 ratio and remained so after adjustment for age, sex, and APOE4 carrier status.
- Overall and parasympathetic networks were negatively associated with GFAP.
- The relationship between the parasympathetic CAN and GFAP was moderated by APOE4 carrier status, wherein APOE4 carriers with low parasympathetic CAN connectivity displayed the highest plasma GFAP concentrations (B = 910.00, P = .004).
- Sensorimotor connectivity was not associated with any plasma AD biomarkers, as expected.
- The present study findings suggest that CAN function is associated with plasma AD biomarker levels.
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Study details
- Study designmeta-analysis
- Participants122
- Evidence strengthHigh
How this study scored 80/100
Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies. Scored zero for effect reported because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 45 of the 56 points we could judge it on, which is 80 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer's research & therapy) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 12 / 12 | A meta-analysis pooling many studies |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 122 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38851772) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 45 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 45 of the 56 points we could judge it on is 80 out of 100. |
| Total | 80 / 100 | — |
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APA 7th
Lohman, T., Kapoor, A., Engstrom, A. C., Shenasa, F., Alitin, J. P. M., Gaubert, A., et al. (2024). Central autonomic network dysfunction and plasma Alzheimer's disease biomarkers in older adults. Alzheimer's research & therapy. https://doi.org/10.1186/s13195-024-01486-9
Vancouver
Lohman T, Kapoor A, Engstrom AC, Shenasa F, Alitin JPM, Gaubert A, et al. Central autonomic network dysfunction and plasma Alzheimer's disease biomarkers in older adults. Alzheimer's research & therapy. 2024. doi:10.1186/s13195-024-01486-9. PMID: 38851772.
BibTeX
@article{lohman2024-38851772,
author = {Lohman, Trevor and Kapoor, Arunima and Engstrom, Allison C and Shenasa, Fatemah and Alitin, John Paul M and Gaubert, Aimee and Rodgers, Kathleen E and Bradford, David and others},
title = {{Central autonomic network dysfunction and plasma Alzheimer's disease biomarkers in older adults}},
journal = {Alzheimer's research \& therapy},
year = {2024},
doi = {10.1186/s13195-024-01486-9},
pmid = {38851772},
url = {https://doi.org/10.1186/s13195-024-01486-9}
}