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Home › Research › TREM2 and immune genetics

Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism

Stephen P Schauer, Chang Hoon Cho, Gloriia Novikova, Gillie A Roth, Julie Lee, Anup D Sharma, Alejandro R Foley, Carl Ng et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024-08-01

This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

✓ Peer-reviewed alzhub usefulness score 46 out of 100. TREM2 and immune genetics

Topic: Inflammation, microglia and astrocytes

We report CSF soluble TREM2 (sTREM2) and CSF chitinase-3-like protein 1 (CHI3L1/YKL-40) as PD biomarkers for the TREM2 agonist hPara.09. The respective reduction of sTREM2 and elevation of CHI3L1 in brain and CSF after TREM2 agonist treatment correlated with transient microglia proliferation and clustering. CSF CHI3L1 and sTREM2 reflect microglial TREM2 agonism and can be used as clinical PD biomarkers to monitor TREM2 activity in the brain. HIGHLIGHTS: CSF soluble triggering receptor expressed on myeloid cells 2 (sTREM2) reflects brain target engagement for a novel TREM2 agonist, hPara.09. CSF chitinase-3-like protein 1 reflects microglial TREM2 agonism. Both can be used as clinical fluid biomarkers to monitor TREM2 activity in brain.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Schauer, S. P., Cho, C. H., Novikova, G., Roth, G. A., Lee, J., Sharma, A. D., et al. (2024). Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.13921

Vancouver

Schauer SP, Cho CH, Novikova G, Roth GA, Lee J, Sharma AD, et al. Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024. doi:10.1002/alz.13921. PMID: 39090679.

BibTeX

@article{schauer2024-39090679,
  author  = {Schauer, Stephen P and Cho, Chang Hoon and Novikova, Gloriia and Roth, Gillie A and Lee, Julie and Sharma, Anup D and Foley, Alejandro R and Ng, Carl and others},
  title   = {{Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.13921},
  pmid    = {39090679},
  url     = {https://doi.org/10.1002/alz.13921}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

Key findings

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Study details

How this study scored 46/100
How this study's score is builtJournal tier 9 of 10; Journal's citation record left out, no data; Study design 0 of 12; Strength of evidence 1 of 5; Peer-review validation 10 of 10; How recent 4 of 5; Sample size 0 of 4; Effect reported 0 of 3; Studied in people 0 of 3; Randomised / blinded 0 of 2; Times cited left out, no data; Citations per year left out, no data; Impact for its field and year left out, no data; Cited by studies here left out, no data; Still being cited left out, no data; Senior author's track record left out, no data; Institution's track record left out, no data; Multi-centre collaboration left out, no data; Indexed in PubMed 2 of 2; Free to read left out, no data. 26 of the 56 points it could be judged on, which is 46 of 100. Total 46 of 100.26 of the 56 points we could judge = 46 of 100

Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 26 of the 56 points we could judge it on, which is 46 out of 100.

ComponentPointsWhy
Journal tier 9 / 10 Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association)
Journal's citation record — / 4 No journal record from OpenAlex — left out of this score
Study design 0 / 12 No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence 1 / 5 Rated “low” in our summary
Peer-review validation 10 / 10 Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent 4 / 5 2024 — within 3 year(s) of the newest study here
Sample size 0 / 4 Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported 0 / 3 No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people 0 / 3 Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded 0 / 2 No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited — / 7 No citation count (not found in OpenAlex) — left out of this score
Citations per year — / 5 No citation count or no year — left out of this score
Impact for its field and year — / 6 No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here — / 6 Not yet checked against this library's citation graph — left out of this score
Still being cited — / 4 No yearly citation counts — left out of this score
Senior author's track record — / 4 Senior author's record not available — left out of this score
Institution's track record — / 3 No institution listed in OpenAlex — left out of this score
Multi-centre collaboration — / 3 Institutions not listed — left out of this score
Indexed in PubMed 2 / 2 Indexed in PubMed (PMID 39090679)
Free to read — / 2 Access not recorded — left out of this score
Points 26 / 56 Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 26 of the 56 points we could judge it on is 46 out of 100.
Total 46 / 100 —

What each of these 20 components measures, and what this score is not →

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