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Value proposition of retinal imaging in Alzheimer's disease screening: A review of eight evolving trends
Victor T T Chan, An Ran Ran, Siegfried K Wagner, Herbert Y H Hui, Xiaoyan Hu, Ho Ko, Sharon Fekrat, Yaxing Wang et al.. Progress in retinal and eye research, 2024-08-22
Topic: Plasma and spinal-fluid biomarkers
Alzheimer's disease (AD) is the leading cause of dementia worldwide. Current diagnostic modalities of AD generally focus on detecting the presence of amyloid β and tau protein in the brain (for example, positron emission tomography [PET] and cerebrospinal fluid testing), but these are limited by their high cost, invasiveness, and lack of expertise. Retinal imaging exhibits potential in AD screening and risk stratification, as the retina provides a platform for the optical visualization of the central nervous system in vivo, with vascular and neuronal changes that mirror brain pathology. Given the paradigm shift brought by advances in artificial intelligence and the emergence of disease-modifying therapies, this article aims to summarize and review the current literature to highlight 8 trends in an evolving landscape regarding the role and potential value of retinal imaging in AD screening.
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APA 7th
Chan, V. T. T., Ran, A. R., Wagner, S. K., Hui, H. Y. H., Hu, X., Ko, H., et al. (2024). Value proposition of retinal imaging in Alzheimer's disease screening: A review of eight evolving trends. Progress in retinal and eye research. https://doi.org/10.1016/j.preteyeres.2024.101290
Vancouver
Chan VTT, Ran AR, Wagner SK, Hui HYH, Hu X, Ko H, et al. Value proposition of retinal imaging in Alzheimer's disease screening: A review of eight evolving trends. Progress in retinal and eye research. 2024. doi:10.1016/j.preteyeres.2024.101290. PMID: 39173942.
BibTeX
@article{chan2024-39173942,
author = {Chan, Victor T T and Ran, An Ran and Wagner, Siegfried K and Hui, Herbert Y H and Hu, Xiaoyan and Ko, Ho and Fekrat, Sharon and Wang, Yaxing and others},
title = {{Value proposition of retinal imaging in Alzheimer's disease screening: A review of eight evolving trends}},
journal = {Progress in retinal and eye research},
year = {2024},
doi = {10.1016/j.preteyeres.2024.101290},
pmid = {39173942},
url = {https://doi.org/10.1016/j.preteyeres.2024.101290}
}
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Key findings
- Alzheimer's disease (AD) is the leading cause of dementia worldwide.
- Current diagnostic modalities of AD generally focus on detecting the presence of amyloid β and tau protein in the brain (for example, positron emission tomography [PET] and cerebrospinal fluid testing), but these are limited by their high cost, invasiveness, and lack of expertise.
- Retinal imaging exhibits potential in AD screening and risk stratification, as the retina provides a platform for the optical visualization of the central nervous system in vivo, with vascular and neuronal changes that mirror brain pathology.
- Given the paradigm shift brought by advances in artificial intelligence and the emergence of disease-modifying therapies, this article aims to summarize and review the current literature to highlight 8 trends in an evolving landscape regarding the role and potential value of retinal imaging in AD screening.
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Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 24 of the 56 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Progress in retinal and eye research) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39173942) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 24 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 24 of the 56 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
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