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Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease
Son HJ, Kim JS, Bateman RJ, Kim S, Llibre-Guerra JJ, Day GS, Chhatwal JP, Berman SB et al.. Neurology, 2024-09-13
Topic: Amyloid, tau and blood-test diagnosis
Background and objectives It remains unknown whether the associations between protective lifestyles and sporadic dementia risk reported in observational studies also affect age at symptom onset (AAO) in autosomal dominant Alzheimer disease (ADAD) with predominant genetic influences. We investigated the associations between resilience-related life experiences and interindividual AAO variability in ADAD. Methods We performed a longitudinal and confirmatory analysis of the Dominantly Inherited Alzheimer Network prospective observational cohort (January 2009-June 2018, follow-up duration 2.13 ± 2.22 years), involving clinical, CSF, and lifestyle/behavioral assessments.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Son, H. J., Kim, J. S., Bateman, R. J., Kim, S., Llibre-Guerra, J. J., Day, G. S., et al. (2024). Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease. Neurology. https://doi.org/10.1212/wnl.0000000000209766
Vancouver
Son HJ, Kim JS, Bateman RJ, Kim S, Llibre-Guerra JJ, Day GS, et al. Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease. Neurology. 2024. doi:10.1212/wnl.0000000000209766. PMID: 39270149.
BibTeX
@article{son2024-39270149,
author = {Son, H. J. and Kim, J. S. and Bateman, R. J. and Kim, S. and Llibre-Guerra, J. J. and Day, G. S. and Chhatwal, J. P. and Berman, S. B. and others},
title = {{Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease}},
journal = {Neurology},
year = {2024},
doi = {10.1212/wnl.0000000000209766},
pmid = {39270149},
url = {https://doi.org/10.1212/wnl.0000000000209766}
}
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Key findings
- We investigated the associations between resilience-related life experiences and interindividual AAO variability in ADAD.
- Methods We performed a longitudinal and confirmatory analysis of the Dominantly Inherited Alzheimer Network prospective observational cohort (January 2009-June 2018, follow-up duration 2.13 ± 2.22 years), involving clinical, CSF, and lifestyle/behavioral assessments.
- We performed a 2-pronged comprehensive resilience assessment in each cohort.
- Cohort 1, incorporating the general resilience definition (cognitive maintenance [Clinical Dementia Rating = 0] despite high pathology), included carriers during the periods of significant CSF p-tau181 variability and grouped into resilience/resistance outcome bins according to the dichotomous pathologic and cognitive statuses, subcategorized by the estimated years from expected symptom onset (EYO).
Why it matters
This longitudinal analysis of the Dominantly Inherited Alzheimer Network cohort examined whether resilience-related life experiences relate to variability in age at symptom onset in autosomal dominant Alzheimer's disease. It reports associations with onset timing and does not show that any experience treats, cures or prevents the disease.
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Study details
- Study designlongitudinal study
- Participants103
- Effect size56.25%; 57.34%; 71.43%
- Evidence strengthModerate
How this study scored 56/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 54 of the 96 points we could judge it on, which is 56 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 103 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.5 citations a year over 4 year(s) since 2024 |
| Impact for its field and year | 1 / 6 | Cited 0.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39270149) |
| Free to read | 2 / 2 | Free to read |
| Points | 54 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 54 of the 96 points we could judge it on is 56 out of 100. |
| Total | 56 / 100 | — |
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