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Primary Tauopathy With Logopenic/Semantic Mixed Progressive Aphasia and Frontotemporal Dementia-like Behavior
Akihiro Takasaki, Yoshiyuki Nishio, Yuto Satake, Matasaburo Kobayashi, Mariko Sakai, Kohji Mori, Kazunari Ishii, Manabu Ikeda. Cognitive and Behavioral Neurology, 2025-04-18
Topic: Brain proteins, microglia and lab models
Here we present the cases of two individuals with language and behavioral symptoms indicative of the early clinical manifestations of both Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD). Phonological language symptoms similar to those evident in logopenic variant primary progressive aphasia suggested AD pathology, while semantic impairment and behavioral changes (ie, abnormal eating behavior and disinhibition) suggested a diagnosis of FTLD. Multimodal neuroimaging studies revealed underlying neuropathology indicative of primary tauopathy with presumable 3/4-repeat isoform, devoid of amyloid deposition. We suggest that these cases may represent a previously unrecognized syndrome associated with non-Alzheimer primary tauopathy.
Key findings
- Multimodal neuroimaging studies revealed underlying neuropathology indicative of primary tauopathy with presumable 3/4-repeat isoform, devoid of amyloid deposition.
- We suggest that these cases may represent a previously unrecognized syndrome associated with non-Alzheimer primary tauopathy.
Why it matters
Two individuals with language and behavioral symptoms suggesting both Alzheimer's disease and frontotemporal lobar degeneration had neuroimaging indicating primary tauopathy without amyloid deposition. The authors suggest these cases may represent a previously unrecognized syndrome, based on only two cases.
Study details
- Evidence strengthLow
How this study scored 29/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cognitive and Behavioral Neurology) |
| Journal's citation record | 0 / 4 | Cognitive and Behavioral Neurology: journal h-index 66 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 1 / 6 | Cited 0.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Manabu Ikeda: h-index 9 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | The University of Osaka: institution h-index 1,138 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40249666) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 29 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Takasaki, A., Nishio, Y., Satake, Y., Kobayashi, M., Sakai, M., Mori, K., et al. (2025). Primary Tauopathy With Logopenic/Semantic Mixed Progressive Aphasia and Frontotemporal Dementia-like Behavior. Cognitive and Behavioral Neurology. https://doi.org/10.1097/wnn.0000000000000391
Vancouver
Takasaki A, Nishio Y, Satake Y, Kobayashi M, Sakai M, Mori K, et al. Primary Tauopathy With Logopenic/Semantic Mixed Progressive Aphasia and Frontotemporal Dementia-like Behavior. Cognitive and Behavioral Neurology. 2025. doi:10.1097/wnn.0000000000000391. PMID: 40249666.
BibTeX
@article{takasaki2025-40249666,
author = {Takasaki, Akihiro and Nishio, Yoshiyuki and Satake, Yuto and Kobayashi, Matasaburo and Sakai, Mariko and Mori, Kohji and Ishii, Kazunari and Ikeda, Manabu},
title = {{Primary Tauopathy With Logopenic/Semantic Mixed Progressive Aphasia and Frontotemporal Dementia-like Behavior}},
journal = {Cognitive and Behavioral Neurology},
year = {2025},
doi = {10.1097/wnn.0000000000000391},
pmid = {40249666},
url = {https://doi.org/10.1097/wnn.0000000000000391}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.