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Network-based gene prioritization using hybrid scoring for complex disease module discovery
Sveva Bonomi, Loris Bottelli, Elisa Oltra, Tiziana Alberio. Scientific Reports, 2026-09-19
Topic: Brain proteins, microglia and lab models
In each case the framework recovered known disease genes and identified biologically coherent, disease-specific modules: in AD, 17 stable high-confidence genes and modules enriched in lipid and cholesterol metabolism and amyloid precursor protein processing; in PD, 17 stable genes and modules associated with mitophagy, ubiquitin-proteasome signaling, and mitochondrial dysfunction; in RA, 20 stable genes and modules enriched in antigen presentation and JAK-STAT cytokine signaling. All code, data, and results are publicly available to ensure reproducibility.
Key findings
- In each case the framework recovered known disease genes and identified biologically coherent, disease-specific modules: in AD, 17 stable high-confidence genes and modules enriched in lipid and cholesterol metabolism and amyloid precursor protein processing; in PD, 17 stable genes and modules associated with mitophagy, ubiquitin-proteasome signaling, and mitochondrial dysfunction; in RA, 20 stable genes and modules enriched in antigen presentation and JAK-STAT cytokine signaling.
- All code, data, and results are publicly available to ensure reproducibility.
Why it matters
This describes a computational framework that recovered known disease genes and identified gene modules for Alzheimer's and other diseases. It is a gene prioritization method and does not test or demonstrate any treatment, cure or prevention.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 32/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Scientific Reports) |
| Journal's citation record | 3 / 4 | Scientific Reports: journal h-index 463 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Tiziana Alberio: h-index 23 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | University of Insubria: institution h-index 420 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Total | 32 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Bonomi, S., Bottelli, L., Oltra, E., & Alberio, T. (2026). Network-based gene prioritization using hybrid scoring for complex disease module discovery. Scientific Reports. https://doi.org/10.1038/s41598-026-71419-z
Vancouver
Bonomi S, Bottelli L, Oltra E, Alberio T. Network-based gene prioritization using hybrid scoring for complex disease module discovery. Scientific Reports. 2026. doi:10.1038/s41598-026-71419-z.
BibTeX
@article{bonomi2026-0913eda7,
author = {Bonomi, Sveva and Bottelli, Loris and Oltra, Elisa and Alberio, Tiziana},
title = {{Network-based gene prioritization using hybrid scoring for complex disease module discovery}},
journal = {Scientific Reports},
year = {2026},
doi = {10.1038/s41598-026-71419-z},
url = {https://doi.org/10.1038/s41598-026-71419-z}
}
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