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40/100

✓ Peer-reviewed alzhub usefulness score 40 out of 100. Vascular contributions

Topic: Brain proteins, microglia and lab models

White matter hyperintensities (WMHs) and cerebral β-amyloid (Aβ) have been characterized as clinically significant biomarkers associated with greater cognitive decline and incidence of Alzheimer's Disease (AD) dementia. However, it remains unclear how their regional manifestations co-contribute to domain-specific cognition and dementia onset. We investigated 200 cognitively normal (CN) and 523 individuals with mild cognitive impairment (MCI). We first quantified regional WMHs and Aβ accumulation in the four cerebral lobes. Next, we evaluated the effects of both WMHs and Aβ in each lobe on memory, executive function (EF), language, and visuospatial function. We used Cox proportional hazard models to determine the contributions of both regional WMHs and Aβ to dementia progression. In CN individuals, greater WMHs in parietal and temporal regions were associated with poorer EF beyond Aβ. In MCI individuals, greater Aβ burden in all lobes were associated with poorer memory, EF, and language abilities beyond WMHs. Lastly, both greater occipital WMHs and Aβ predicted progression to dementia. Temporo-parietal WMHs may drive early decline in EF beyond regional Aβ, while occipital WMHs play a critical role in disease progression to AD dementia beyond regional Aβ, highlighting the complex interplay of regional WMHs and Aβ on domain-specific cognitive and clinical function.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Choo, C. M., & Tan, C. H. (2025). Effects of regional white matter hyperintensities and β-amyloid on domain-specific cognition and progression to dementia. Brain and Cognition. https://doi.org/10.1016/j.bandc.2025.106332

Vancouver

Choo CM, Tan CH. Effects of regional white matter hyperintensities and β-amyloid on domain-specific cognition and progression to dementia. Brain and Cognition. 2025. doi:10.1016/j.bandc.2025.106332. PMID: 40561557.

BibTeX

@article{choo2025-40561557,
  author  = {Choo, Cameron Mavericks and Tan, Chin Hong},
  title   = {{Effects of regional white matter hyperintensities and β-amyloid on domain-specific cognition and progression to dementia}},
  journal = {Brain and Cognition},
  year    = {2025},
  doi     = {10.1016/j.bandc.2025.106332},
  pmid    = {40561557},
  url     = {https://doi.org/10.1016/j.bandc.2025.106332}
}

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Key findings

White matter hyperintensities (WMHs) and cerebral β-amyloid (Aβ) have been characterized as clinically significant biomarkers associated with greater cognitive decline and incidence of Alzheimer's Disease (AD) dementia.
In CN individuals, greater WMHs in parietal and temporal regions were associated with poorer EF beyond Aβ.
In MCI individuals, greater Aβ burden in all lobes were associated with poorer memory, EF, and language abilities beyond WMHs.

Why it matters

In people with mild cognitive impairment, amyloid burden was linked to poorer memory, executive function and language, while white matter hyperintensities in certain regions predicted progression to dementia. This is observational and does not test any treatment, but it may help explain how vascular and amyloid changes together affect thinking.

Study details

Participants523
Evidence strengthLow

How this study scored 40/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Brain and Cognition)
Journal's citation record	2 / 4	Brain and Cognition: journal h-index 185 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	523 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 4 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.3 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 2.5× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Chin Hong Tan: h-index 19 (OpenAlex, whole career)
Institution's track record	1 / 3	Nanyang Technological University: institution h-index 981 (OpenAlex)
Multicenter collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40561557)
Free to read	2 / 2	Free to read
Total	40 / 100	—

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