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44/100

✓ Peer-reviewed alzhub usefulness score 44 out of 100. Vascular contributions

Topic: Brain proteins, microglia and lab models

WMH burden positively correlated to Neurofilament-Light (NfL) and pTau181. Executive function and processing speed negatively correlated to WMH burden. GFAP positively correlated to pTau181 and negatively correlated to executive function. NfL, GFAP, pTau181, and Amyloid beta 42/Amyloid beta 40 (Aβ42/Aβ40) ratio independently moderated, the relationship between executive function/processing speed and WMH burden. Inflammatory mechanisms represented by GFAP were linked to tau pathology and WMH and also moderated the association between WMH on cognitive performance.

Key findings

WMH burden positively correlated to Neurofilament-Light (NfL) and pTau181.
Executive function and processing speed negatively correlated to WMH burden.
GFAP positively correlated to pTau181 and negatively correlated to executive function.
NfL, GFAP, pTau181, and Amyloid beta 42/Amyloid beta 40 (Aβ42/Aβ40) ratio independently moderated, the relationship between executive function/processing speed and WMH burden.
Inflammatory mechanisms represented by GFAP were linked to tau pathology and WMH and also moderated the association between WMH on cognitive performance.

Why it matters

In this cross-sectional study, white matter hyperintensity burden correlated with neurofilament-light and pTau181, and several blood markers moderated the relationship between executive function or processing speed and white matter hyperintensities. The authors link inflammatory mechanisms represented by GFAP to tau pathology and white matter hyperintensities, but the study does not test any treatment, cure, or prevention.

Study details

Study designcross-sectional
Participants583
Evidence strengthLow

How this study scored 44/100

Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (The Journal of Prevention of Alzheimer s Disease)
Journal's citation record	0 / 4	The Journal of Prevention of Alzheimer s Disease: journal h-index 63 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	583 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 4 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.3 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 2.5× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Nagaendran Kandiah: h-index 45 (OpenAlex, whole career)
Institution's track record	1 / 3	Nanyang Technological University: institution h-index 981 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40753006)
Free to read	2 / 2	Free to read
Total	44 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Sandhu, G. K., Vipin, A., Leonardo, J., Zailan, F. Z., Tanoto, P., Lee, F. P. H. E., et al. (2025). The role of Tau, amyloid-β and neuroinflammation in the association between cognition and white matter hyperintensities in a southeast Asian cohort. The Journal of Prevention of Alzheimer s Disease. https://doi.org/10.1016/j.tjpad.2025.100300

Vancouver

Sandhu GK, Vipin A, Leonardo J, Zailan FZ, Tanoto P, Lee FPHE, et al. The role of Tau, amyloid-β and neuroinflammation in the association between cognition and white matter hyperintensities in a southeast Asian cohort. The Journal of Prevention of Alzheimer s Disease. 2025. doi:10.1016/j.tjpad.2025.100300. PMID: 40753006.

BibTeX

@article{sandhu2025-40753006,
  author  = {Sandhu, Gurveen Kaur and Vipin, Ashwati and Leonardo, Jacklyn and Zailan, Fatin Zahra and Tanoto, Pricilia and Lee, Faith Phemie Hui En and Sim, Xin Ying and Ghildiyal, Smriti and others},
  title   = {{The role of Tau, amyloid-β and neuroinflammation in the association between cognition and white matter hyperintensities in a southeast Asian cohort}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100300},
  pmid    = {40753006},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100300}
}

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