Home › Research › Biomarkers
Concordance Between Amyloid-PET Quantification and Real-World Visual Reads
Zeltzer E, Schonhaut DR, Mundada NS, Blazhenets G, Soleimani-Meigooni DN, Cho H, Ranasinghe KG, Windon C et al.. JAMA neurology, 2025-09-01
Topic: Amyloid, tau and blood-test diagnosis
Results Of 18 293 participants included in the parent study, scan images were available for 10 774 (59%), of which Centiloids were successfully calculated for 10 361 (96%).
Key findings
- Results Of 18 293 participants included in the parent study, scan images were available for 10 774 (59%), of which Centiloids were successfully calculated for 10 361 (96%).
Why it matters
This study reports how often amyloid PET scans could be quantified using Centiloids, with 10,361 of 10,774 available scans successfully calculated. It is a technical report about scan measurement and does not address treating, curing, or preventing Alzheimer's disease.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Study designcross-sectional
- Participants294
- Effect size0.2%; 1.8%; 3.1%
- Evidence strengthLow
How this study scored 63/100
Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA neurology) |
| Journal's citation record | 2 / 4 | JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 294 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 41 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 13.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 5 / 6 | Cited 26.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 2 / 4 | Cited 41 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Renaud La Joie: h-index 73 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Michigan: institution h-index 2,240 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 13 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40720133) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 63 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1001/jamaneurol.2025.2218
- PubMed: 40720133
- Original source →
- Free full text: PubMed Central →
Full text: free to read — PubMed Central lists this copy as free to read: the link above (checked 10 Oct 2026).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Zeltzer, E., Schonhaut, D. R., Mundada, N. S., Blazhenets, G., Soleimani-Meigooni, D. N., Cho, H., et al. (2025). Concordance Between Amyloid-PET Quantification and Real-World Visual Reads. JAMA neurology. https://doi.org/10.1001/jamaneurol.2025.2218
Vancouver
Zeltzer E, Schonhaut DR, Mundada NS, Blazhenets G, Soleimani-Meigooni DN, Cho H, et al. Concordance Between Amyloid-PET Quantification and Real-World Visual Reads. JAMA neurology. 2025. doi:10.1001/jamaneurol.2025.2218. PMID: 40720133.
BibTeX
@article{zeltzer2025-40720133,
author = {Zeltzer, E. and Schonhaut, D. R. and Mundada, N. S. and Blazhenets, G. and Soleimani-Meigooni, D. N. and Cho, H. and Ranasinghe, K. G. and Windon, C. and others},
title = {{Concordance Between Amyloid-PET Quantification and Real-World Visual Reads}},
journal = {JAMA neurology},
year = {2025},
doi = {10.1001/jamaneurol.2025.2218},
pmid = {40720133},
url = {https://doi.org/10.1001/jamaneurol.2025.2218}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 18.
Later studies that cite this one
8 studies in the alzhub library list this one in their references.
Related studies in Biomarkers
Also tagged “classification”
835 studies in the library carry the topic tag “classification”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 835 tagged studies.