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Overactive bladder medications and risk of emergency hospital admissions with delirium in adults without dementia: self-controlled case series
Kathryn Richardson, Irene Petersen, Katharina Mattishent, Oby Otu Enwo, Nicholas Steel, Duncan Edwards, Jalesh N. Panicker, Stuart Irving et al.. Age and Ageing, 2025-08-29
Topic: Risk, prevention and care in population studies
The risk of delirium admissions was elevated for the first 1-30 days of prescriptions [IRR 1.54 (95% CI 1.30-1.82) for men, 1.44 (1.22-1.70) for women] and whilst reducing over time for women [1.10 (0.94-1.29) for 91-365 days of prescriptions], it remained elevated for men [1.38 (1.17-1.64)]. There was some evidence of greater delirium IRRs in older men and men initiating higher dosages. In secondary analysis of 502 adults initiating mirabegron (non-anticholinergic beta-3 receptor agonist), the delirium IRRs during the first 1-30 and 31-90 days of prescriptions were 1.15 (0.76-1.75) and 0.72 (0.47-1.09). We observed increased hospital admission rates with delirium for adults without dementia whilst prescribed OAB anticholinergics, but not whilst prescribed mirabegron. Delirium risk remained raised for longer for men and was greater in older men. Alternative management options for OAB in older people should be considered before prescribing anticholinergic medications.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Richardson, K., Petersen, I., Mattishent, K., Enwo, O. O., Steel, N., Edwards, D., et al. (2025). Overactive bladder medications and risk of emergency hospital admissions with delirium in adults without dementia: self-controlled case series. Age and Ageing. https://doi.org/10.1093/ageing/afaf308
Vancouver
Richardson K, Petersen I, Mattishent K, Enwo OO, Steel N, Edwards D, et al. Overactive bladder medications and risk of emergency hospital admissions with delirium in adults without dementia: self-controlled case series. Age and Ageing. 2025. doi:10.1093/ageing/afaf308. PMID: 41143862.
BibTeX
@article{richardson2025-41143862,
author = {Richardson, Kathryn and Petersen, Irene and Mattishent, Katharina and Enwo, Oby Otu and Steel, Nicholas and Edwards, Duncan and Panicker, Jalesh N. and Irving, Stuart and others},
title = {{Overactive bladder medications and risk of emergency hospital admissions with delirium in adults without dementia: self-controlled case series}},
journal = {Age and Ageing},
year = {2025},
doi = {10.1093/ageing/afaf308},
pmid = {41143862},
url = {https://doi.org/10.1093/ageing/afaf308}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- The risk of delirium admissions was elevated for the first 1-30 days of prescriptions [IRR 1.54 (95% CI 1.30-1.82) for men, 1.44 (1.22-1.70) for women] and whilst reducing over time for women [1.10 (0.94-1.29) for 91-365 days of prescriptions], it remained elevated for men [1.38 (1.17-1.64)].
- There was some evidence of greater delirium IRRs in older men and men initiating higher dosages.
- In secondary analysis of 502 adults initiating mirabegron (non-anticholinergic beta-3 receptor agonist), the delirium IRRs during the first 1-30 and 31-90 days of prescriptions were 1.15 (0.76-1.75) and 0.72 (0.47-1.09).
- We observed increased hospital admission rates with delirium for adults without dementia whilst prescribed OAB anticholinergics, but not whilst prescribed mirabegron.
- Delirium risk remained raised for longer for men and was greater in older men.
Why it matters
This study found that adults without dementia had higher rates of hospital admission with delirium while taking overactive bladder anticholinergic medications, but not while taking mirabegron. The risk stayed raised longer for men and was greater in older men, suggesting alternative management options should be considered before prescribing anticholinergics.
Study details
- Participants293
- Effect sizeRR 1.54 (95% CI 1.30-1.82)
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Age and Ageing) |
| Journal's citation record | 2 / 4 | Age and Ageing: journal h-index 231 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 293 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 1 / 6 | Cited 0.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Yoon Kong Loke: h-index 72 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 8 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41143862) |
| Free to read | 2 / 2 | Free to read |
| Total | 45 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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