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Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein
Suzuki T, Oishi M, Marshak DR, Czernik AJ, Nairn AC, Greengard P.. The EMBO journal, 1994-03-01
Topic: Brain proteins, microglia and lab models
Accumulation of the amyloid A beta peptide, which is derived from a larger precursor protein (APP), and the formation of plaques, are major events believed to be involved in the etiology of Alzheimer's disease. Abnormal regulation of the metabolism of APP may contribute to the deposition of plaques. APP is an integral membrane protein containing several putative phosphorylation sites within its cytoplasmic domain.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Suzuki, T., Oishi, M., Marshak, D. R., Czernik, A. J., Nairn, A. C., & Greengard, P. (1994). Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. The EMBO journal. https://doi.org/10.1002/j.1460-2075.1994.tb06360.x
Vancouver
Suzuki T, Oishi M, Marshak DR, Czernik AJ, Nairn AC, Greengard P. Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. The EMBO journal. 1994. doi:10.1002/j.1460-2075.1994.tb06360.x. PMID: 8131745.
BibTeX
@article{suzuki1994-8131745,
author = {Suzuki, T. and Oishi, M. and Marshak, D. R. and Czernik, A. J. and Nairn, A. C. and Greengard, P.},
title = {{Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein}},
journal = {The EMBO journal},
year = {1994},
doi = {10.1002/j.1460-2075.1994.tb06360.x},
pmid = {8131745},
url = {https://doi.org/10.1002/j.1460-2075.1994.tb06360.x}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Abnormal regulation of the metabolism of APP may contribute to the deposition of plaques.
- APP is an integral membrane protein containing several putative phosphorylation sites within its cytoplasmic domain.
- We report here that APP is phosphorylated at Thr668 by p34cdc2 protein kinase (cdc2 kinase) in vitro, and in a cell cycle-dependent manner in vivo.
- At the G2/M phase of the cell cycle, when APP phosphorylation is maximal, the levels of mature APP (mAPP) and immature APP (imAPP) do not change significantly.
Why it matters
This study found that APP is phosphorylated at Thr668 by cdc2 kinase in a cell cycle-dependent manner in vitro and in vivo. It is laboratory research on APP metabolism and does not test any treatment, cure, or prevention.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The EMBO journal) |
| Journal's citation record | 4 / 4 | The EMBO Journal: journal h-index 563 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1994 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 216 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 6.4 citations a year over 34 year(s) since 1994 |
| Impact for its field and year | 3 / 6 | Cited 3.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 1 / 4 | Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Paul Greengard: h-index 206 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Rockefeller University: institution h-index 1,200 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 8131745) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1002/j.1460-2075.1994.tb06360.x
- PubMed: 8131745
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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