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Age, adaptive behavior, and Alzheimer disease in Down syndrome: cross-sectional and longitudinal analyses
Rasmussen DE, Sobsey D.. American journal of mental retardation : AJMR, 1994-09-01
Topic: Amyloid, tau and blood-test diagnosis
Cross-sectional and longitudinal analyses were used to compare age-related changes in adaptive functioning in institutionalized adults with and without Down syndrome. Cross-sectional analysis showed significant differences related to level of functioning but not to age or etiology of disability. Longitudinal analysis showed a pattern of decline in self-help and communication skills in several individuals with Down syndrome older than 40. The case of an adult with Down syndrome with confirmed Alzheimer pathology at postmortem was presented. Results were discussed in relation to aging and the likelihood of Alzheimer-like changes in individuals with Down syndrome.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Rasmussen, D. E., & Sobsey, D. (1994). Age, adaptive behavior, and Alzheimer disease in Down syndrome: cross-sectional and longitudinal analyses. American journal of mental retardation : AJMR.
Vancouver
Rasmussen DE, Sobsey D. Age, adaptive behavior, and Alzheimer disease in Down syndrome: cross-sectional and longitudinal analyses. American journal of mental retardation : AJMR. 1994. PMID: 7803032.
BibTeX
@article{rasmussen1994-7803032,
author = {Rasmussen, D. E. and Sobsey, D.},
title = {{Age, adaptive behavior, and Alzheimer disease in Down syndrome: cross-sectional and longitudinal analyses}},
journal = {American journal of mental retardation : AJMR},
year = {1994},
pmid = {7803032}
}
Built from the record alzhub holds for this paper, not looked up. This record has no DOI, so the citation leaves it out. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Cross-sectional analysis showed significant differences related to level of functioning but not to age or etiology of disability.
- Results were discussed in relation to aging and the likelihood of Alzheimer-like changes in individuals with Down syndrome.
Why it matters
This cross-sectional and longitudinal study found declines in self-help and communication skills in some adults with Down syndrome older than 40, and presented one case with confirmed Alzheimer pathology at postmortem. It describes age-related changes, not any treatment, cure or prevention.
Study details
- Study designcross-sectional
- Evidence strengthModerate
How this study scored 37/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record and institution's track record, so those were left out: it earned 34 of the 93 points we could judge it on, which is 37 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (American journal of mental retardation : AJMR) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1994 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 38 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.1 citations a year over 34 year(s) since 1994 |
| Impact for its field and year | 2 / 6 | Cited 2.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Dick Sobsey: h-index 17 (OpenAlex, whole career) |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 0 institution(s) in 0 countries — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 7803032) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 34 / 93 | Scored on 18 of 20 parts. We have no data for the rest, so they are left out: 34 of the 93 points we could judge it on is 37 out of 100. |
| Total | 37 / 100 | — |
What each of these 20 components measures, and what this score is not →
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