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AIDS dementia complex and HIV-1 brain infection: clinical-virological correlations
Brew BJ, Rosenblum M, Cronin K, Price RW.. Annals of neurology, 1995-10-01
Topic: Risk, prevention and care in population studies
To evaluate the presence and distribution of central nervous system infection by human immunodeficiency virus type 1 (HIV-1), we used immunohistochemical methods to map the HIV-1 p24 core protein in the brains of 55 autopsied patients with acquired immunodeficiency syndrome (AIDS). In a subset of 40 of these patients who had undergone antemortem neurological evaluation of the AIDS dementia complex (ADC), we analyzed the relation between the severities of the viral infection and clinical dysfunction. Viral antigen was detected in macrophages and cells with morphological and immunohistochemical characteristics of microglia as well as multinucleated cells.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Brew, B. J., Rosenblum, M., Cronin, K., & Price, R. W. (1995). AIDS dementia complex and HIV-1 brain infection: clinical-virological correlations. Annals of neurology. https://doi.org/10.1002/ana.410380404
Vancouver
Brew BJ, Rosenblum M, Cronin K, Price RW. AIDS dementia complex and HIV-1 brain infection: clinical-virological correlations. Annals of neurology. 1995. doi:10.1002/ana.410380404. PMID: 7574452.
BibTeX
@article{brew1995-7574452,
author = {Brew, B. J. and Rosenblum, M. and Cronin, K. and Price, R. W.},
title = {{AIDS dementia complex and HIV-1 brain infection: clinical-virological correlations}},
journal = {Annals of neurology},
year = {1995},
doi = {10.1002/ana.410380404},
pmid = {7574452},
url = {https://doi.org/10.1002/ana.410380404}
}
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Key findings
- In a subset of 40 of these patients who had undergone antemortem neurological evaluation of the AIDS dementia complex (ADC), we analyzed the relation between the severities of the viral infection and clinical dysfunction.
- Viral antigen was detected in macrophages and cells with morphological and immunohistochemical characteristics of microglia as well as multinucleated cells.
- The distribution of antigen-positive cells preferentially involved certain deep brain structures, especially the globus pallidus, other basal ganglia nuclei, and the central white matter.
- Overall, the presence and frequency of infected cells were highly correlated with the histological findings of multinucleated-cell encephalitis and in general with the clinical ADC stage.
Why it matters
This study mapped HIV-1 virus protein in the brains of 55 autopsied AIDS patients and related the amount of infection to the severity of AIDS dementia complex. It describes how HIV infects brain immune cells rather than neurons directly, which may inform understanding of dementia caused by HIV but does not address Alzheimer's disease treatment or prevention.
Study details
- Evidence strengthLow
How this study scored 45/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Annals of neurology) |
| Journal's citation record | 3 / 4 | Annals of Neurology: journal h-index 437 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1995 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 257 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.8 citations a year over 33 year(s) since 1995 |
| Impact for its field and year | 3 / 6 | Cited 6.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 7 other studies in this library |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Richard W. Price: h-index 84 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Memorial Sloan Kettering Cancer Center: institution h-index 1,931 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 7574452) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 45 / 100 | — |
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