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Fas antigen expression in brains of patients with Alzheimer-type dementia
Nishimura T, Akiyama H, Yonehara S, Kondo H, Ikeda K, Kato M, Iseki E, Kosaka K.. Brain research, 1995-10-01
Topic: Amyloid, tau and blood-test diagnosis
Fas antigen (CD95) is a cell surface protein that mediates apoptosis. We have investigated the immunohistochemical localization of Fas antigen in postmortem brain tissue from control subjects, patients with Alzheimer-type dementia (ATD), and from a few patients with diffuse Lewy body disease, progressive supranuclear palsy and adrenoleukodystrophy. In all brains, including controls, vascular endothelial cells and residual blood plasma were weakly stained. In ATD brains, senile plaques and a small number of star-like cells were brains of patients with neurological diseases other than ATD. In double immunostaining for Fas and glial fibrillary acidic protein (GFAP), a small number of cells were positive for both antigens. The majority of Fas-positive astrocytes were, however, negative for GFAP. This implies the downregulation of GFAP production in these cells. Doubly labeled astrocytes were also found around senile plaques, suggesting that the Fas immunoreactivity in senile plaques was derived from astrocytic membranes. The results of this study indicate that Fas antigen is expressed by a subset of reactive astrocytes in degenerative neurological diseases. Such astrocytes may undergo the Fas-mediated apoptotic process.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Nishimura, T., Akiyama, H., Yonehara, S., Kondo, H., Ikeda, K., Kato, M., et al. (1995). Fas antigen expression in brains of patients with Alzheimer-type dementia. Brain research. https://doi.org/10.1016/0006-8993(95)00699-q
Vancouver
Nishimura T, Akiyama H, Yonehara S, Kondo H, Ikeda K, Kato M, et al. Fas antigen expression in brains of patients with Alzheimer-type dementia. Brain research. 1995. doi:10.1016/0006-8993(95)00699-q. PMID: 8556323.
BibTeX
@article{nishimura1995-8556323,
author = {Nishimura, T. and Akiyama, H. and Yonehara, S. and Kondo, H. and Ikeda, K. and Kato, M. and Iseki, E. and Kosaka, K.},
title = {{Fas antigen expression in brains of patients with Alzheimer-type dementia}},
journal = {Brain research},
year = {1995},
doi = {10.1016/0006-8993(95)00699-q},
pmid = {8556323},
url = {https://doi.org/10.1016/0006-8993(95)00699-q}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Doubly labeled astrocytes were also found around senile plaques, suggesting that the Fas immunoreactivity in senile plaques was derived from astrocytic membranes.
- The results of this study indicate that Fas antigen is expressed by a subset of reactive astrocytes in degenerative neurological diseases.
Why it matters
In postmortem brain tissue, Fas antigen was found in senile plaques and in a subset of reactive astrocytes in Alzheimer-type dementia. This is a tissue study from 1995 and does not test any treatment, cure or prevention.
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Study details
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Brain research) |
| Journal's citation record | 3 / 4 | Brain Research: journal h-index 399 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1995 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 126 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.8 citations a year over 33 year(s) since 1995 |
| Impact for its field and year | 3 / 6 | Cited 4.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Kenji Kosaka: h-index 61 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Kyoto University: institution h-index 1,156 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 8556323) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 40 / 100 | — |
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