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Localization of manganese superoxide dismutase in the cerebral cortex and hippocampus of Alzheimer-type senile dementia
Maeda M, Takagi H, Hattori H, Matsuzaki T.. Osaka city medical journal, 1997-06-01
Topic: Brain proteins, microglia and lab models
Manganese-superoxide dismutase (Mn-SOD) was localized in the cerebral cortex and hippocampus of patients with Alzheimer-type senile dementia (ATD) by immunocytochemistry and the relationship of Mn-SOD with two major pathological features of ATD, i.e., senile plaques and neurofibrillar tangles (NFTs), was examined. Many astrocytes in senile plaques exhibited strong immunoreactivity for both Mn-SOD and glial fibrillar acidic protein (GFAP) on serial section analysis. This suggests that Mn-SOD scavenger system is associated with the formation of senile plaques. On the other hand, Mn-SOD immunoreactivity was not significant in NFT-loaded neurons.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Maeda, M., Takagi, H., Hattori, H., & Matsuzaki, T. (1997). Localization of manganese superoxide dismutase in the cerebral cortex and hippocampus of Alzheimer-type senile dementia. Osaka city medical journal.
Vancouver
Maeda M, Takagi H, Hattori H, Matsuzaki T. Localization of manganese superoxide dismutase in the cerebral cortex and hippocampus of Alzheimer-type senile dementia. Osaka city medical journal. 1997. PMID: 9343989.
BibTeX
@article{maeda1997-9343989,
author = {Maeda, M. and Takagi, H. and Hattori, H. and Matsuzaki, T.},
title = {{Localization of manganese superoxide dismutase in the cerebral cortex and hippocampus of Alzheimer-type senile dementia}},
journal = {Osaka city medical journal},
year = {1997},
pmid = {9343989}
}
Built from the record alzhub holds for this paper, not looked up. This record has no DOI, so the citation leaves it out. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- This suggests that Mn-SOD scavenger system is associated with the formation of senile plaques.
- On the other hand, Mn-SOD immunoreactivity was not significant in NFT-loaded neurons.
Why it matters
In brain tissue from patients with Alzheimer-type senile dementia, astrocytes in senile plaques showed strong immunoreactivity for manganese superoxide dismutase, while NFT-loaded neurons did not. This is a descriptive tissue study suggesting an association with plaque formation, not a treatment or cure.
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Study details
- Evidence strengthLow
How this study scored 27/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record and senior author's track record, so those were left out: it earned 25 of the 92 points we could judge it on, which is 27 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Osaka city medical journal) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1997 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 17 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.5 citations a year over 31 year(s) since 1997 |
| Impact for its field and year | 1 / 6 | Cited 0.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 0 / 3 | Osaka City University: institution h-index 452 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 9343989) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 25 / 92 | Scored on 18 of 20 parts. We have no data for the rest, so they are left out: 25 of the 92 points we could judge it on is 27 out of 100. |
| Total | 27 / 100 | — |
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