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Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia
Jeffrey Alan Kaye, Tim Swihart, Diane B. Howieson, A. Dame, Milar M. Moore, T. Karnos, Richard M. Camicioli, Melvyn J. Ball et al.. Neurology, 1997-05-01
Topic: Brain imaging, connectivity and assessment
NoD as well as PreD subjects had significant, time-dependent decreases in hippocampal and parahippocampal volume. Rates of volume loss between the groups did not significantly differ. PreD cases had significantly smaller hippocampi when asymptomatic. Parahippocampal volume did not differ between PreD and NoD cases. Significant time-dependent temporal lobe atrophy was present only in PreD. Hippocampal and parahippocampal atrophy occurs at a similar rate regardless of diagnostic group. Those who develop dementia may have smaller hippocampi to begin with, but become symptomatic because of accelerated loss of temporal lobe volume. Temporal lobe volume loss may mark the beginning of the disease process within six years prior to dementia onset.
Key findings
- NoD as well as PreD subjects had significant, time-dependent decreases in hippocampal and parahippocampal volume.
- Rates of volume loss between the groups did not significantly differ.
- PreD cases had significantly smaller hippocampi when asymptomatic.
- Parahippocampal volume did not differ between PreD and NoD cases.
- Significant time-dependent temporal lobe atrophy was present only in PreD.
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Study details
- Evidence strengthLow
How this study scored 40/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 23 of the 58 points we could judge it on, which is 40 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1997 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 9153461) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 23 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 23 of the 58 points we could judge it on is 40 out of 100. |
| Total | 40 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Kaye, J. A., Swihart, T., Howieson, D. B., Dame, A., Moore, M. M., Karnos, T., et al. (1997). Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia. Neurology. https://doi.org/10.1212/wnl.48.5.1297
Vancouver
Kaye JA, Swihart T, Howieson DB, Dame A, Moore MM, Karnos T, et al. Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia. Neurology. 1997. doi:10.1212/wnl.48.5.1297. PMID: 9153461.
BibTeX
@article{kaye1997-9153461,
author = {Kaye, Jeffrey Alan and Swihart, Tim and Howieson, Diane B. and Dame, A. and Moore, Milar M. and Karnos, T. and Camicioli, Richard M. and Ball, Melvyn J. and others},
title = {{Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia}},
journal = {Neurology},
year = {1997},
doi = {10.1212/wnl.48.5.1297},
pmid = {9153461},
url = {https://doi.org/10.1212/wnl.48.5.1297}
}
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