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Medial temporal structures relate to memory impairment in Alzheimer's disease: an MRI volumetric study
Mori E, Yoneda Y, Yamashita H, Hirono N, Ikeda M, Yamadori A.. Journal of neurology, neurosurgery, and psychiatry, 1997-08-01
Topic: Amyloid, tau and blood-test diagnosis
Objectives Memory impairment is not only the earliest clinical symptom but a central and prominent feature throughout the course of Alzheimer's disease. Alzheimer related pathological alterations in the medial temporal structures may account for the memory impairments in patients with Alzheimer's disease. The aim of this study was to elucidate the role of the medial temporal structures in memory impairment caused by Alzheimer's disease. Methods Using high resolution MRI and a semiautomated image analysis technique, volumes of the medial temporal structures (amygdaloid complex, hippocampal formation, subiculum, and parahippocampal gyrus) were measured, and correlations between atrophy of each structure and memory dysfunction in patients with Alzheimer's disease were examined. Results Patients with Alzheimer's disease showed poor performance on verbal and non-verbal memory tests, and MRI volumetry showed a significant volume reduction of the medial temporal lobe structures. Volumes of the amygdaloid complex and of the subiculum correlated with memory performance. Stepwise regression analyses disclosed that the volume of the right amygdaloid complex specifically predicted visual memory function and to some extent verbal memory function, and that the volume of the left subiculum specifically predicted verbal memory function. Atrophy of the hippocampus did not predict severity of memory impairment. Conclusions The presence of perihippocampal damage involving the amygdala proper, its surrounding cortex, and the subiculum further increased the severity of memory impairment attributable to hippocampal damage in Alzheimer's disease.
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APA 7th
Mori, E., Yoneda, Y., Yamashita, H., Hirono, N., Ikeda, M., & Yamadori, A. (1997). Medial temporal structures relate to memory impairment in Alzheimer's disease: an MRI volumetric study. Journal of neurology, neurosurgery, and psychiatry. https://doi.org/10.1136/jnnp.63.2.214
Vancouver
Mori E, Yoneda Y, Yamashita H, Hirono N, Ikeda M, Yamadori A. Medial temporal structures relate to memory impairment in Alzheimer's disease: an MRI volumetric study. Journal of neurology, neurosurgery, and psychiatry. 1997. doi:10.1136/jnnp.63.2.214. PMID: 9285461.
BibTeX
@article{mori1997-9285461,
author = {Mori, E. and Yoneda, Y. and Yamashita, H. and Hirono, N. and Ikeda, M. and Yamadori, A.},
title = {{Medial temporal structures relate to memory impairment in Alzheimer's disease: an MRI volumetric study}},
journal = {Journal of neurology, neurosurgery, and psychiatry},
year = {1997},
doi = {10.1136/jnnp.63.2.214},
pmid = {9285461},
url = {https://doi.org/10.1136/jnnp.63.2.214}
}
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Key findings
- Results Patients with Alzheimer's disease showed poor performance on verbal and non-verbal memory tests, and MRI volumetry showed a significant volume reduction of the medial temporal lobe structures.
Why it matters
Patients with Alzheimer's disease had poor verbal and non-verbal memory test performance and significant volume reduction in medial temporal lobe structures. Volumes of the amygdaloid complex and subiculum correlated with memory performance, while hippocampal atrophy did not predict severity of memory impairment.
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Study details
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neurology, neurosurgery, and psychiatry) |
| Journal's citation record | 3 / 4 | Journal of Neurology Neurosurgery & Psychiatry: journal h-index 336 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1997 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 141 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.5 citations a year over 31 year(s) since 1997 |
| Impact for its field and year | 3 / 6 | Cited 5.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 1 / 4 | Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Atsushi Yamadori: h-index 46 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Tohoku University: institution h-index 880 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 9285461) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 40 / 100 | — |
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Read the original
- DOI: 10.1136/jnnp.63.2.214
- PubMed: 9285461
- Original source →
- Free full text: Journal of Neurology Neurosurgery & Psychiatry →
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