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α-Synuclein in Lewy bodies
Maria Grazia Spillantini, Marie Luise Schmidt, Virginia M.‐Y. Lee, John Q. Trojanowski, Ross Jakes, Michel Goedert. Nature, 1997-08-28
Topic: Brain proteins, microglia and lab models
We do not hold a plain-English summary of this study yet. Use the links to the original below for its abstract and findings.
Why it matters
Reports that alpha-synuclein is found in Lewy bodies.
How this study scored 60/100
Published in a top-tier journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 57 of the 95 points we could judge it on, which is 60 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 10 / 10 | Tier 1 — top-tier general journal (Nature) |
| Journal's citation record | 4 / 4 | Nature: journal h-index 1,841 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1997 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 8,395 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 270.8 citations a year over 31 year(s) since 1997 |
| Impact for its field and year | 6 / 6 | Cited 70.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 4 / 4 | Cited 1,324 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Michel Goedert: h-index 147 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Cambridge: institution h-index 1,973 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 9278044) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 57 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 57 of the 95 points we could judge it on is 60 out of 100. |
| Total | 60 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Spillantini, M. G., Schmidt, M. L., Lee, V. M., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997). α-Synuclein in Lewy bodies. Nature. https://doi.org/10.1038/42166
Vancouver
Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M. α-Synuclein in Lewy bodies. Nature. 1997. doi:10.1038/42166. PMID: 9278044.
BibTeX
@article{spillantini1997-9278044,
author = {Spillantini, Maria Grazia and Schmidt, Marie Luise and Lee, Virginia M.‐Y. and Trojanowski, John Q. and Jakes, Ross and Goedert, Michel},
title = {{α-Synuclein in Lewy bodies}},
journal = {Nature},
year = {1997},
doi = {10.1038/42166},
pmid = {9278044},
url = {https://doi.org/10.1038/42166}
}
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