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optical
151 studies tagged optical, dated 1986-08-01 to 2026-10-22. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Retinal biomarkers and dementia risk: A review of evidence across the 14 Lancet modifiable risk factors for dementia 2026-10-22
- Multimodal Retinal Imaging for the Detection of Early Alzheimer’s Disease: Combining Biochemical, Structural, and Vascular Biomarkers 2026-08-17
- Electroretinography as a Noninvasive Biomarker of Alzheimer’s Disease and Related Dementias in Older Adults: A Systematic Scoping Review 2026-07-30
Studies
151 studies carry this tag.
Date range
1986 to 2026
Top journals
- Journal of Alzheimer's disease : JAD 13
- Alzheimer's & dementia (Amsterdam, Netherlands) 7
- Progress in retinal and eye research 7
- Alzheimer's & dementia : the journal of the Alzheimer's Association 4
- Investigative ophthalmology & visual science 4
89 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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As the only central nervous system tissue that can be directly imaged non-invasively using widely available technology, the retina offers a uniquely accessible window into the brain.
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Alzheimer’s disease (AD) pathology is increasingly recognized to manifest in the retina, offering a non-invasive window for early biomarker discovery.
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Irrespective of ERG modality, ADRD was consistently associated with retinal dysfunction marked by impaired synaptic transmission and delayed neural processing across retinal circuits.
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These findings demonstrate spatially concordant vascular and neuronal degeneration in the outer retina in preclinical AD.
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BackgroundRetinal thickness has been associated with neurocognitive conditions such as Alzheimer's disease (AD).ObjectiveRetinal cell layer thickness was evaluated for associations with neurodegenerative protein biomarkers glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) in plasma, vitreous humor, and aqueous humor.
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Small palpebral fissure is an independent and previously unnoticed risk factor for glaucoma surgical failure, affecting both minimally invasive and filtration procedures.
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The high metabolic demand of retinal neurons requires tightly regulated mechanisms to maintain homeostasis and ensure the efficient clearance of metabolic waste and excess water.
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Subjective cognitive decline (SCD) serves as an initial symptom of preclinical Alzheimer's disease (AD).
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A narrative synthesis approach will be used to analyse the results, with meta-analysis performed if there is sufficient data.
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50/100
Reductions of FALFF in temporal regions, especially the left superior temporal gyrus (STG) in MCI patients, were linked to decreased RNFL thickness and increased FAZ area significantly.
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Intergrader agreements for overall 3 × 3 mm image quality and quantitative assessment of VD and FAZ ranged between 71% and 87% (52 images).
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Alzheimer's disease (AD) is a neurodegenerative disease characterized by amyloid beta (Aβ)-containing extracellular plaques and tau-containing intracellular neurofibrillary tangles.
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Vision impairment (VI) and eye diseases such as age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma and cataract have been reported to be associated with cognitive impairment and dementia, however, to date, very little attempt has been made to collate and synthesizes such literature.
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43/100
While Alzheimer's disease and other neurodegenerative diseases have traditionally been viewed as brain disorders, there is growing evidence indicating their manifestation in the eyes as well.
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The eye is closely connected to the brain, providing a unique window to detect pathological changes in the brain.
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Alzheimer's disease (AD) is the leading cause of dementia worldwide.
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HIGHLIGHTS: We demonstrated the diagnostic performance of qLRP in Alzheimer's disease.
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43/100
This commentary article delves into the transformative role of optical coherence tomography angiography (OCTA) in diagnosing and managing a wide array of eye conditions, including diabetic retinopathy, age-related macular degeneration, retinal vein occlusions, and white dot syndromes.
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The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of Alzheimer's disease (AD).
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Both cohorts revealed diminished choriocapillaris signals, demonstrating the highest discriminatory capability (area under the receiver operating characteristic curve: SS-OCTA 0.913, SD-OCTA 0.991; P < 0.001).
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43/100
An extensive exploration of lacrimal fluid molecular biomarkers in understanding and diagnosing a spectrum of ocular and systemic diseases is presented.
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Glaucoma is a group of optic neuropathies and the world's leading cause of irreversible blindness.
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The fractal dimension (FD) and global vein width were significantly correlated with the CI (P < 0.05).
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With the aging of the global population, the health care burden of Alzheimer's disease (AD) and dementia is considered to increase dramatically in the coming decades.
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The retinal reflectance spectra in the 450-585 nm wavelengths exhibited a significant difference in individuals with increasing brain amyloid.
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One hundred twenty-eight participants (21.9%) developed dementia over a median of 7.1 years.
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Ophthalmic biomarkers have long played a critical role in diagnosing and managing ocular diseases.
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Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of Aβ plaques and neurofibrillary tangles, resulting in synaptic loss and neurodegeneration.
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52/100
Pupillometry is a measurement of pupil dilation commonly performed as part of neurological assessments.
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General baseline characteristics of the study population were mean (standard deviation) age, 58.1 (8.8) years; 47% women.
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In this survey study, all types of objectively measured VI were associated with a higher dementia prevalence.
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This retrospective case-control study aimed to investigate associations between disease severity of Alzheimer's dementia (AD) and macular thickness.
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Optical coherence tomography angiography (OCTA) is a novel, noninvasive imaging technique, which provides depth resolved visualization of microvasculature of the retina and choroid.
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There is a pressing need for novel diagnostic and progression biomarkers of neurodegeneration.
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Alzheimer's disease (AD) is a progressive neurodegenerative disorder impacting cognition, function, and behavior in the elderly population.
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The conjunctival microcirculation is an accessible complex network of micro vessels whose quantitative assessment can reveal microvascular haemodynamic properties.
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52/100
Ninety-one eyes of AD patients and 53 eyes of patients with other dementias were included.
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Most risk factors under study (i.e., hyperglycemia, unhealthy diet, lower cardiorespiratory fitness, smoking, alcohol consumption, and hypertension) were significantly associated with lower retinal sensitivity and lower RNFL thickness.
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There is consistent evidence that dementia affects driving ability.
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64/100
NfL, Aβ40, Aβ42, GFAP, and p-tau181 were detected in all AH samples by Simoa platform.
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Over the past decade, ocular imaging strategies have greatly advanced the diagnosis and follow-up of patients with optic neuropathies.
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HR signs have a significative association with cardiovascular, cerebrovascular and other systemic diseases.
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The early diagnosis of neurodegenerative disorders is still an open issue despite the many efforts to address this problem.
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Alzheimer's Disease (AD) is one of the main neurodegenerative diseases worldwide.
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Our systematic review indicates that a majority of studies examining the vision-cognition relationship report that VI is associated with more cognitive decline, cognitive impairment or dementia among older adults.
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3xTg mice exhibited nuanced deficits in RGC electrical signaling, axonal transport, and synaptic integrity that exceeded normal age-related decrements in RGC function in age- and sex-matched healthy control mice.
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We report that by early prion disease (50% timepoint), discrete fluorescent foci appeared adjacent to the optic disc.
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Patients with Alzheimer's disease have difficulty maintaining independent living abilities as the disease progresses, causing an increased burden of care on family caregivers and the healthcare system and related financial strain.
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Structural and functional alterations in the microcirculation by systemic hypertension can cause significant organ damage at the eye, heart, brain, and kidneys.
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The progressive aging of the population will notably increase the burden of those diseases which leads to a disabling situation, such as Alzheimer's disease (AD) and ophthalmological diseases that cause a visual impairment (VI).
From across this tag
7 of the 151 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 7. The same 7 appear here every time.
- Validation of Optical Coherence Tomography Retinal Segmentation in Neurodegenerative Disease
- Retinal abnormalities in early Alzheimer's disease
- Optical coherence tomography and neurodegeneration: are eyes the windows to the brain?
- The application of retinal fundus camera imaging in dementia: A systematic review
- Protein and Imaging Biomarkers in the Eye for Early Detection of Alzheimer's Disease
- High occurrence rate of glaucoma among patients with Alzheimer's disease
- Optical Coherence Tomography Angiography in Neurodegenerative Disorders