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Hyperspectral Retinal Imaging as a Non-Invasive Marker to Determine Brain Amyloid Status
Purna Poudel, Shaun M Frost, Shaun Eslick, Hamid R Sohrabi, Kevin Taddei, Ralph N Martins, Eugene Hone. Journal of Alzheimer's disease : JAD, 2024
Topic: Plasma and spinal-fluid biomarkers
The retinal reflectance spectra in the 450-585 nm wavelengths exhibited a significant difference in individuals with increasing brain amyloid. The retinal features in the superior view showed higher inter-subject variability. A classification model was trained to differentiate individuals with varying amyloid levels using the spectra of extracted retinal features. The performance of the spectral classification model was dependent upon retinal features and showed 0.758-0.879 accuracy, 0.718-0.909 sensitivity, 0.764-0.912 specificity, and 0.745-0.891 area under curve for the right eye. This study highlights the spectral variation of retinal features associated with brain amyloid loads. It also demonstrates the feasibility of the retinal hyperspectral imaging technique as a potential method to identify individuals in the preclinical phase of AD as an inexpensive alternative to brain imaging.
Key findings
- The retinal reflectance spectra in the 450-585 nm wavelengths exhibited a significant difference in individuals with increasing brain amyloid.
- The retinal features in the superior view showed higher inter-subject variability.
- A classification model was trained to differentiate individuals with varying amyloid levels using the spectra of extracted retinal features.
- The performance of the spectral classification model was dependent upon retinal features and showed 0.758-0.879 accuracy, 0.718-0.909 sensitivity, 0.764-0.912 specificity, and 0.745-0.891 area under curve for the right eye.
- This study highlights the spectral variation of retinal features associated with brain amyloid loads.
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Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 24 of the 56 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39121128) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 24 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 24 of the 56 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Poudel, P., Frost, S. M., Eslick, S., Sohrabi, H. R., Taddei, K., Martins, R. N., et al. (2024). Hyperspectral Retinal Imaging as a Non-Invasive Marker to Determine Brain Amyloid Status. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-240631
Vancouver
Poudel P, Frost SM, Eslick S, Sohrabi HR, Taddei K, Martins RN, et al. Hyperspectral Retinal Imaging as a Non-Invasive Marker to Determine Brain Amyloid Status. Journal of Alzheimer's disease : JAD. 2024. doi:10.3233/jad-240631. PMID: 39121128.
BibTeX
@article{poudel2024-39121128,
author = {Poudel, Purna and Frost, Shaun M and Eslick, Shaun and Sohrabi, Hamid R and Taddei, Kevin and Martins, Ralph N and Hone, Eugene},
title = {{Hyperspectral Retinal Imaging as a Non-Invasive Marker to Determine Brain Amyloid Status}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2024},
doi = {10.3233/jad-240631},
pmid = {39121128},
url = {https://doi.org/10.3233/jad-240631}
}
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