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Retinal microvasculature and incident dementia over 10 years: The Three-City-Alienor cohort
Sara Cristina Lima Rebouças, Audrey Cougnard-Gregoire, Louis Arnould, Marie-Noëlle Delyfer, Cédric Schweitzer, Jean-François Korobelnik, Alexandra Foubert-Samier, Carol Y Cheung et al.. Alzheimer's & dementia (Amsterdam, Netherlands), 2023-10-22
Topic: Plasma and spinal-fluid biomarkers
One hundred twenty-eight participants (21.9%) developed dementia over a median of 7.1 years. In Cox proportional hazards models adjusted for sociodemographic characteristics, apolipoprotein E (APOE) ε4, and vascular factors, increased retinal arteriolar tortuosity was associated with all-cause dementia (hazard ratio per standard deviation increase, 1.21; 95% confidence interval: 1.02-1.44). Wider retinal calibers and a higher venular tortuosity were associated with mixed/vascular dementia, but not Alzheimer's disease. Fractal dimensions were not associated with dementia. Changes in the retinal microvasculature were associated with dementia risk. More studies are needed to replicate these findings and determine which features might help identify persons at risk at an early stage. HIGHLIGHTS: The retinal microvasculature might reflect the brain microvasculatureWe explored the association between retinal vascular features and incident dementia584 participants from the Three-City-Alienor cohort were followed-up over 10 yearsIncreased arteriolar tortuosity and venular calibers were associated with dementia riskRetinal imaging might help identify persons at risk of future dementia.
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APA 7th
Rebouças, S. C. L., Cougnard-Gregoire, A., Arnould, L., Delyfer, M.-N., Schweitzer, C., Korobelnik, J.-F., et al. (2023). Retinal microvasculature and incident dementia over 10 years: The Three-City-Alienor cohort. Alzheimer's & dementia (Amsterdam, Netherlands). https://doi.org/10.1002/dad2.12480
Vancouver
Rebouças SCL, Cougnard-Gregoire A, Arnould L, Delyfer M.-N, Schweitzer C, Korobelnik J.-F, et al. Retinal microvasculature and incident dementia over 10 years: The Three-City-Alienor cohort. Alzheimer's & dementia (Amsterdam, Netherlands). 2023. doi:10.1002/dad2.12480. PMID: 37915467.
BibTeX
@article{reboucas2023-37915467,
author = {Rebouças, Sara Cristina Lima and Cougnard-Gregoire, Audrey and Arnould, Louis and Delyfer, Marie-Noëlle and Schweitzer, Cédric and Korobelnik, Jean-François and Foubert-Samier, Alexandra and Cheung, Carol Y and others},
title = {{Retinal microvasculature and incident dementia over 10 years: The Three-City-Alienor cohort}},
journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
year = {2023},
doi = {10.1002/dad2.12480},
pmid = {37915467},
url = {https://doi.org/10.1002/dad2.12480}
}
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Key findings
- One hundred twenty-eight participants (21.9%) developed dementia over a median of 7.1 years.
- In Cox proportional hazards models adjusted for sociodemographic characteristics, apolipoprotein E (APOE) ε4, and vascular factors, increased retinal arteriolar tortuosity was associated with all-cause dementia (hazard ratio per standard deviation increase, 1.21; 95% confidence interval: 1.02-1.44).
- Wider retinal calibers and a higher venular tortuosity were associated with mixed/vascular dementia, but not Alzheimer's disease.
- Fractal dimensions were not associated with dementia.
- Changes in the retinal microvasculature were associated with dementia risk.
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Study details
- Study designlongitudinal study
- Participants584
- Effect size21.9%
- Evidence strengthModerate
How this study scored 73/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 41 of the 56 points we could judge it on, which is 73 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia (Amsterdam, Netherlands)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 584 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37915467) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 41 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 41 of the 56 points we could judge it on is 73 out of 100. |
| Total | 73 / 100 | — |
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