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Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI
Susan M. Landau, Danielle Jenine Harvey, Cindee M. Madison, Robert A. Koeppe, Eric M. Reiman, Norman L. Foster, Michael Walter Weiner, William J. Jagust. Neurobiology of Aging, 2011
Topic: Risk, prevention and care in population studies
This study compared FDG-PET and clinical measurements in elderly subjects with memory disturbance to examine relationships between glucose metabolism and cognitive or functional scores. The researchers found that low baseline glucose metabolism predicted subsequent cognitive and functional decline, and longitudinal glucose metabolism decline was associated with concurrent decline. Ultimately, the study demonstrated that glucose metabolism serves as a sensitive measure of change in cognition and functional ability.
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APA 7th
Landau, S. M., Harvey, D. J., Madison, C. M., Koeppe, R. A., Reiman, E. M., Foster, N. L., et al. (2011). Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI. Neurobiology of Aging. https://doi.org/10.1016/j.neurobiolaging.2009.07.002
Vancouver
Landau SM, Harvey DJ, Madison CM, Koeppe RA, Reiman EM, Foster NL, et al. Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI. Neurobiology of Aging. 2011. doi:10.1016/j.neurobiolaging.2009.07.002. PMID: 19660834.
BibTeX
@article{landau2011-19660834,
author = {Landau, Susan M. and Harvey, Danielle Jenine and Madison, Cindee M. and Koeppe, Robert A. and Reiman, Eric M. and Foster, Norman L. and Weiner, Michael Walter and Jagust, William J.},
title = {{Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI}},
journal = {Neurobiology of Aging},
year = {2011},
doi = {10.1016/j.neurobiolaging.2009.07.002},
pmid = {19660834},
url = {https://doi.org/10.1016/j.neurobiolaging.2009.07.002}
}
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Key findings
- Low glucose metabolism at baseline predicted subsequent ADAS-cog and FAQ decline.
- Longitudinal glucose metabolism decline was associated with concurrent ADAS-cog and FAQ decline.
- FDG-ROI values have greater statistical power than ADAS-cog to detect attenuation of cognitive decline in AD and MCI patients.
Why it matters
Examines how cognitive, functional and FDG-PET imaging measures of decline relate to each other in Alzheimer's disease and mild cognitive impairment.
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How this study scored 37/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, journal's citation record, times cited, citations per year, impact for its field and year, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 22 of the 59 points we could judge it on, which is 37 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of Aging) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2011 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (OpenAlex dates this DOI to 2009, the record says 2011; OpenAlex values not used) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 19660834) |
| Free to read | 2 / 2 | Free to read |
| Points | 22 / 59 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 22 of the 59 points we could judge it on is 37 out of 100. |
| Total | 37 / 100 | — |
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