Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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36/100
In a study of two congeneric rodent species, sex differences in hippocampal size were predicted by sex-specific patterns of spatial cognition.
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One hundred patients with Parkinson's disease (PD) and five patients with progressive supranuclear palsy were questioned about the frequency, circumstances, and consequences of falling.
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Hip fracture has long been considered a major threat to survival in aged populations.
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Psychiatric symptoms attributable to vitamin B12 deficiency have been described for decades.
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The aims of this study were to estimate the incidence of acute confusional state (ACS), its predisposing factors and consequences in 111 consecutive patients operated for fractured neck of the femur.
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Bedside cognitive screening instruments are used increasingly in clinical and research settings to detect cognitive impairment and to quantify its severity.
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Twenty-two subjects with presumed senile dementia of the Alzheimer's type (SDAT), twenty-two with dementia other than SDAT, twenty with aphasia, and seventeen healthy controls over 50 years of age were examined for intrusions and perseverations.
Why it matters
This study examined intrusions and perseverations in subjects with dementia, aphasia, and healthy controls. It found intrusions were a useful sign of dementia but not specific to Alzheimer's type, and there was no significant correlation between dementia severity and perseverations.
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Measures of gait and balance were undertaken in 11 elderly ambulant patients suffering from senile dementia of Alzheimer type of moderate severity, and in an equal number of healthy non-demented age- and sex-matched controls.
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Medically ill patients diagnosed at index admission as delirious, i.e., suffering cognitive decline and an altered state of consciousness, had higher fatality rates than demented, cognitively intact or depressed patients.
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Higher per-capita food availability was positively associated with dementia outcomes in minimally adjusted models, particularly for the 2005 exposure window, although these associations were substantially attenuated after full covariate adjustment.
Why it matters
Higher per-capita food availability was linked to more dementia in some models, but these links weakened or disappeared after full adjustment, and no significant associations were seen for mortality or the 2015 window. The study cannot show that food availability causes or prevents dementia.
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Through 2022, 5% of fee-for-service beneficiaries with dementia received CACP compared to 3% of MA beneficiaries (p < 0.001).
Why it matters
This study found that use of Medicare's cognitive assessment and care plan services remained low among beneficiaries with dementia through 2022. It does not address treating, curing, or preventing Alzheimer's disease.
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More positive attitudes were associated with lower decisional conflict directly and indirectly through perceived benefits.
Why it matters
This cross-sectional study of 92 family caregivers of people with dementia in South Korea found that more positive attitudes were associated with lower decisional conflict, partly through perceived benefits of advance care planning. The model explained 28.2% of the variance in decisional conflict, suggesting perceived benefits may reduce it.
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The program was effective, as evidenced by the multidimensional health gains achieved.
Why it matters
This multidomain program in 504 older adults found improvements in cognitive, affective, social, and quality of life scores, with high adherence and satisfaction. It lacked a control group, so it cannot prove that the program prevents cognitive decline or dementia.
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Compared to those in rural areas, participants who resided in urban areas during young adulthood had lower late midlife ADI (β = -0.85, p < .05), and better executive function (β = 0.19), processing speed (β = 0.24), and verbal fluency (β = 0.30) (ps < .05) in older adulthood.
Why it matters
Men who lived in urban areas in young adulthood had less neighborhood disadvantage in later midlife and better performance on several cognitive tests in older age. Neighborhood disadvantage partly explained this link, suggesting community conditions across life may matter for cognition, though the study cannot prove cause and effect.
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Dementia is a debilitating disease that leads to a gradual loss of memory and other cognitive abilities and tends to develop in people over 60 years of age.
Why it matters
This study used machine learning and graph analysis to identify patterns and markers for classifying dementia subtypes, with Random Forest performing best among ten models. The authors state the results might help improve diagnostic accuracy, but no treatment or prevention effect is reported.
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Accurate detection of Mild Cognitive Impairment (MCI) is critical for timely intervention and for slowing progression to Alzheimer's disease.
Why it matters
This study developed a deep learning framework using EEG that detected MCI with high accuracy under subject-independent evaluation. The work is about developing an automated diagnostic tool and does not test any treatment or prevention for Alzheimer's disease.
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35/100
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), particularly semaglutide, have demonstrated substantial efficacy for glycemic control and weight management and are increasingly prescribed across diverse populations.
Why it matters
This narrative review synthesizes current evidence on the efficacy and safety of semaglutide for obesity management, focusing on adverse events, treatment persistence, perioperative considerations and special populations. It does not address Alzheimer's disease treatment, cure or prevention.
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Evidence suggests that chronic caregiving stress contributes to biological changes such as immune dysregulation, inflammation, acceleration, aging, and potential cognitive decline in caregivers themselves.
Why it matters
This narrative review reports that chronic caregiving stress is linked to biological changes such as immune dysregulation, inflammation, and potential cognitive decline in spousal caregivers themselves. It concerns caregiver health rather than treating, curing, or preventing Alzheimer's disease in patients.
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Being exposed to a peer who adopted CACP was a strong predictor of providers’ own uptake of CACP.
Why it matters
This study looked at whether doctors are more likely to start billing for dementia care planning visits when a colleague does so. It found that having a peer adopt the billing code was strongly linked to a provider adopting it too, but it does not test any treatment, cure, or prevention of Alzheimer's disease.
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Four themes described how staff perceived spirituality to influence their work to comfort, guide, protect and make meaning.
Why it matters
This qualitative study described four themes in how nursing home staff perceive spirituality to influence their care of residents with advanced dementia. It concerns staff support and comfort in caregiving, not treating, curing or preventing Alzheimer's disease.
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Music therapy has gained recognition as a safe, effective, and person-centered intervention that bridges neuroscience, medicine, and humanities.
Why it matters
This review reports that the strongest evidence for music therapy is in dementia care, where it is described as a safe and person-centered intervention. It does not claim music therapy cures or prevents Alzheimer's disease, and it notes that implementation is limited by workforce shortages, limited reimbursement, and lack of standardized reporting.
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Seventeen articles were included. People with dementia from ethnic minority groups report lower quality care received.
Why it matters
This scoping review found that people with dementia from ethnic minority groups receive lower quality care, are less likely to be prescribed anti-dementia medications, and have lower adherence when prescribed. It identifies barriers to access and adherence but does not test a treatment or cure.
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Lithium is a naturally occurring trace element with established neuroprotective and psychotropic properties at pharmacologic doses.
Why it matters
This county-level study found that areas with high drinking water lithium concentrations had lower dementia prevalence and incidence, while associations with mortality remained uncertain. It is an ecological association and does not test lithium as a treatment, cure, or prevention for Alzheimer's disease.
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Alzheimer's Disease is a complex, chronic illness of increasing prevalence in the US and worldwide.
Why it matters
This report describes a brain health navigator program in a large integrated healthcare system that enrolled over 100 patients in six months with positive patient and caregiver feedback. It addresses care coordination and reimbursement, not treating, curing, or preventing Alzheimer's disease.
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Seventy-six percent (23/30) of enrolled dyads successfully completed the study.
Why it matters
This small 6-week feasibility study found that a virtual nurse-led early palliative care intervention was feasible for people living with dementia and their caregivers, with 76% of enrolled dyads completing the study. It tested feasibility and acceptability only, not whether the intervention improves outcomes.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Frequency and course of mild cognitive impairment in a multiethnic community
- Review of Safety and Efficacy of Sleep Medicines in Older Adults
- “Taxes, death, and trouble”: Role of structural socioeconomic racism on cognitive function for persons racialized as Black
- Increased risk of dementia in patients with primary Sjogren’s syndrome: a nationwide population-based cohort study
- A Pilot Double-Blind Randomized Controlled Trial of Cognitive Training Combined with Transcranial Direct Current Stimulation for Amnestic Mild Cognitive Impairment
- Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension
- Characteristics of nonresponders in a community survey of the elderly
- Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU)
- Multidimensional frailty score for the prediction of postoperative mortality risk
- Neuropathologic substrate of mild cognitive impairment