Home › Research › Cognitive tests and assessment
Association between visual hallucinations and cognitive performance in Lewy body dementia and Alzheimer's disease: A cross-sectional study
Yaqi Yang, Fan Yang, Jinghuan Gan, Shuai Liu, Chen Wen, Lixin Liu, Tianjiao Ren, Jiarui Wang et al.. Journal of Alzheimer s Disease Reports, 2025-05-04
Topic: Risk, prevention and care in population studies
DLB patients had a higher prevalence of VH than AD patients (p < 0.01). The presence of VH predicted lower Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores in both DLB and AD patients (p < 0.01). In DLB patients, VH were associated with lower attention function scores after adjustment (p = 0.027). In AD patients, VH were related to worsened orientation ability after adjustment (p = 0.033). Attention function partially mediated the association between VH and cognition in DLB patients (p < 0.01), whereas orientation function partially mediated this association in AD patients (p < 0.01). VH may independently correlate with deterioration in global cognitive performance. In DLB patients with VH, attentional function appears to be more impaired, whereas in AD patients, orientation function is the most affected. Different cognitive domains may help distinguish between DLB and AD patients with VH.
Key findings
- DLB patients had a higher prevalence of VH than AD patients (p < 0.01).
- The presence of VH predicted lower Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores in both DLB and AD patients (p < 0.01).
- In DLB patients, VH were associated with lower attention function scores after adjustment (p = 0.027).
- In AD patients, VH were related to worsened orientation ability after adjustment (p = 0.033).
- Attention function partially mediated the association between VH and cognition in DLB patients (p < 0.01), whereas orientation function partially mediated this association in AD patients (p < 0.01).
Why it matters
Visual hallucinations were more common in Lewy body dementia than Alzheimer's disease and were linked to lower cognitive scores in both, with attention most affected in Lewy body dementia and orientation most affected in Alzheimer's. Different cognitive domains may help distinguish these two dementias in patients with visual hallucinations, but this does not treat the condition.
Study details
- Participants154
- Evidence strengthLow
How this study scored 38/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer s Disease Reports) |
| Journal's citation record | 0 / 4 | Journal of Alzheimer s Disease Reports: journal h-index 40 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 154 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Yong Ji: h-index 27 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Capital Medical University: institution h-index 643 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40330106) |
| Free to read | 2 / 2 | Free to read |
| Total | 38 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1177/25424823251339132
- PubMed: 40330106
- Original source →
- Free full text: Journal of Alzheimer s Disease Reports →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Yang, Y., Yang, F., Gan, J., Liu, S., Wen, C., Liu, L., et al. (2025). Association between visual hallucinations and cognitive performance in Lewy body dementia and Alzheimer's disease: A cross-sectional study. Journal of Alzheimer s Disease Reports. https://doi.org/10.1177/25424823251339132
Vancouver
Yang Y, Yang F, Gan J, Liu S, Wen C, Liu L, et al. Association between visual hallucinations and cognitive performance in Lewy body dementia and Alzheimer's disease: A cross-sectional study. Journal of Alzheimer s Disease Reports. 2025. doi:10.1177/25424823251339132. PMID: 40330106.
BibTeX
@article{yang2025-40330106,
author = {Yang, Yaqi and Yang, Fan and Gan, Jinghuan and Liu, Shuai and Wen, Chen and Liu, Lixin and Ren, Tianjiao and Wang, Jiarui and others},
title = {{Association between visual hallucinations and cognitive performance in Lewy body dementia and Alzheimer's disease: A cross-sectional study}},
journal = {Journal of Alzheimer s Disease Reports},
year = {2025},
doi = {10.1177/25424823251339132},
pmid = {40330106},
url = {https://doi.org/10.1177/25424823251339132}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.