Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Download bibliography of all 8,018 studies, highest score first: BibTeX (.bib) · RIS (.ris)
Highest usefulness score first. Studies without a score come last.
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This article details the determinant bundle of store choice and the role of price as one of the major components in initial and ongoing store selection.
Why it matters
This study examines grocery store pricing and store choice, not Alzheimer's disease, so it offers nothing on treating, curing or preventing Alzheimer's. It questions internal reference price theory based on consumer surveys.
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Progressive myoclonic epilepsy (PME) is a syndrome characterized by myoclonias, epilepsy, progressive dementia and other neurological deficits.
Why it matters
This paper describes progressive myoclonic epilepsy, a rare syndrome that includes progressive dementia along with myoclonias and epilepsy, often caused by inherited genetic diseases. It recommends considering this diagnosis in severe cases and centralizing treatment, but does not report a treatment or cure for Alzheimer's disease.
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We know that lifestyle changes, such as to diet and exercise regimens, can have an impact on the risk of developing dementia.
Why it matters
This article states that research has revealed socialisation has an important role to play in dementia risk, alongside lifestyle changes such as diet and exercise. It provides no further detail on the size or nature of that effect.
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In January, the NHS presented its long-awaited plan to transform care over the next 10 years.
Why it matters
This article evaluates what the NHS Long-Term Plan means for the future of dementia care. It provides no information on treating, curing or preventing Alzheimer's disease itself.
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And, she noted, data from the 2009-2011 Medical Expenditure Panel Survey have shown that “high-need adults spent more on health care but were less likely to report that the health system works for them.”
Why it matters
This report describes care approaches for high-cost, high-need patients, including assessing needs, developing care plans, engaging patients and families, and coordinating care. It notes that a demonstration showed savings on high-cost beneficiaries, but that misaligned financial incentives are often a barrier to spreading successful care models.
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There is explosive growth in the number of older Americans, who are at higher risk for cancer.
Why it matters
This report notes explosive growth in the number of older Americans, who are at higher risk for cancer, and stresses the need to measure how patients are functioning. It does not report any treatment, cure, or prevention for Alzheimer's disease.
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As Deputy Gibbs’ father says, “I know it’s hard to find people in this world,” he said.
Why it matters
This is a book review of a novel set in rural Appalachia and contains no information about Alzheimer's disease treatment, cure, or prevention. It cannot inform decisions about Alzheimer's care.
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The results were announced earlier this month at a press conference in Washington D.C., and were published in the May American Journal of Psychiatry.
Why it matters
This study found that the rollout of Medicare Part D was plagued by widespread problems, including inappropriate copayments, pharmacies unable to confirm eligibility, and drug plans failing to follow transition policies. It reports that about half the states and Washington, D.C. took emergency action to continue prescription drug coverage under state financing.
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Back to table of contents Previous article Next article Association NewsFull AccessAssembly Votes Challenge Threats to Patient CareKen HausmanKen HausmanSearch for more papers by this authorPublished Online:1 Dec 2006https://doi.org/10.1176/pn.41.23.0004Patient care issues had a prominent place on the agenda for the APA Assembly's November meeting in Washington, D.C., and several dealt with prescribing concerns in a health care environment that is not always patient friendly.
Why it matters
This report describes APA Assembly votes on patient care issues, including a paper intended to protect and encourage clinically and financially appropriate prescribing. It notes concerns that drug formularies are difficult to use in psychiatry because of low nosologic specificity, lack of interchangeability of medicines within a class, and lack of understanding of how psychotropic medications work.
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But advocacy groups, including APA, have been bracing for enormous complications with transitioning these beneficiaries— some 2 million of whom are believed to have mental illness—into the new program.
Why it matters
This is a lawsuit alleging that the federal government is not taking adequate steps to transfer dual-eligible beneficiaries to Medicare Part D prescription drug coverage. It warns that without adequate steps, many dual eligibles may be left without needed prescription drug coverage.
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21/100
But when I imagined the short, awkward conversations that would have been likely to ensue, conversations whose power to irk me would almost certainly be out of all proportion to their length, I always made the same swift choice: leave it.
Why it matters
This essay describes the experience of a person whose husband became 'invisible in plain sight' while living with dementia. It contains no findings on treating, curing, or preventing Alzheimer's disease.
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Hearing loss is a potential risk factor for dementia, but public awareness of this link and its behavioral implications remain poorly understood.
Why it matters
Only 28% of surveyed Canadians knew about the link between hearing loss and dementia, and of those, 17% said they were more likely to seek or continue hearing treatment. This suggests public awareness is low and that simply knowing about the link may not be enough to change behavior, but it does not test whether treating hearing loss prevents dementia.
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16/100
Speech-based cognitive monitoring for Alzheimer's employs various tasks, but whether timing measures transfer across tasks is unclear.
Why it matters
In a small group of 12 senior living residents, speech timing measures did not give the same results across different speaking tasks. This means these measures cannot be used interchangeably for monitoring cognition, and the study is very small and preliminary.
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Over a median follow-up of 13 years, 5,304 participants developed dementia.
Why it matters
In UK Biobank data, certain patterns of lifestyle and health risk factors were linked to higher dementia risk, with the highest risk in people who had multiple risk factors at once. This suggests that addressing combinations of risk factors may help with prevention strategies, but it is an observational study and does not prove that changing these factors prevents dementia.
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INTRODUCTIONDementia research in sub-Saharan Africa remains limited despite rapid population aging and substantial ancestral, environmental, and vascular diversity.
Why it matters
This describes a new long-term study in north-eastern Nigeria that will follow older adults to understand cognitive decline and neurodegeneration in a region where such research is limited. It has enrolled participants and collected samples, but no results on treating, curing, or preventing Alzheimer's are available yet.
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For TabCAT tests, there were no notable floor or ceiling effects, and test scores were associated with age and education as expected.
Why it matters
This study found that tablet-based cognitive tests worked well for measuring thinking skills and detecting cognitive impairment in older adults in Uganda, including people with lower education and literacy. These tools could help identify cognitive problems in places where standard testing is difficult, but the study only tested the assessment tool itself, not any treatment or prevention.
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Pain assessment remains challenging in clinical practice.
Why it matters
Clinicians surveyed said automated facial-analysis systems could be useful for monitoring pain in patients who cannot communicate well, including those with dementia. However, most wanted high accuracy before routine use, and concerns about alert fatigue and fairness were raised, so this is about developing a tool, not treating Alzheimer's.
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INTRODUCTIONThe number of people living with dementia in many African countries is anticipated to treble by 2050.
Why it matters
Nearly 1 in 5 people aged 60 and over in rural Uganda were found to have dementia, with most cases mild or very mild. This shows how common dementia is in this region and highlights the need for services, but it does not test any treatment or prevention.
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BackgroundMultimorbidity is common among U.S. skilled nursing facilities (SNFs) residents and complicates pharmacologic management, yet real-world evidence on treatment patterns in this population remains limited.
Why it matters
Among nursing home residents with multiple health conditions, those with Alzheimer's disease and related dementias were less likely to have a medication order recorded for their conditions. This points to possible gaps in medication management for people with dementia, but it is about prescribing patterns, not treating or preventing Alzheimer's itself.
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ObjectiveTo investigate whether a lifetime history of DSM-5 AUD and correlated indices of alcohol consumption are associated with accelerated age-related cognitive decline in middle-aged and older adults.
Why it matters
People with a lifetime history of alcohol use disorder showed faster age-related decline in total and fluid thinking skills over about 25 years, well before any dementia would typically appear. This suggests heavy lifetime drinking may speed up cognitive aging, but it does not test whether treating alcohol use disorder prevents dementia.
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Compared with controls, adjusted odds of classification into a more impaired CDR category were higher in all tiers (OR 2.55-5.08, 95% CI 1.22-11.34).
Why it matters
This natural history study of CADASIL, a rare inherited cause of stroke and dementia, found that participants had higher odds of being classified into more impaired categories than controls. It describes the course of the disease and does not test any treatment or cure.
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Implications of menopause hormone therapy (MHT) for cognitive aging remain unclear despite decades of research.
Why it matters
In a large observational study, estradiol-based menopause hormone therapy was linked to more favorable cognitive and brain outcomes in APOE-e4 carriers compared with conjugated equine estrogens. These are associations only, and the authors say formulation- and genetic-risk-aware approaches are needed rather than a general recommendation.
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It remains unclear whether the combined conditions confer an excess risk of hypoglycaemia-related hospitalisation beyond the risks associated with either condition alone.
Why it matters
This study found that people with both type 2 diabetes and dementia were hospitalized for low blood sugar far more often than those with either condition alone. It suggests that safer blood sugar management is needed for this group, but it does not test any treatment for Alzheimer's disease itself.
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ImportanceLower relative amplitude of the rest-activity pattern has been associated with cognitive decline and incident dementia in older adults, but its relationship with domain-specific cognitive performance during midlife is less well characterized.
Why it matters
In this cross-sectional study of 851 midlife adults, lower relative amplitude of the rest-activity pattern was linked to modestly poorer performance on some cognitive tests. Because it only looked at one point in time, it cannot show whether this pattern causes cognitive decline or whether changing it would help.
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IntroductionRemote cognitive assessments offer an accessible, scalable way to support clinical characterization and longitudinal monitoring of cognition.
Why it matters
This study found that a remote, self-administered cognitive test was completed by most patients in an Alzheimer's treatment clinic, including those with moderate dementia. It shows the test is feasible to use, but it does not test any treatment or show whether remote testing improves patient outcomes.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Development and Validation of a Tool to Predict Onset of Mild Cognitive Impairment and Alzheimer Dementia
- Intradialytic Cognitive and Exercise Training May Preserve Cognitive Function
- Sex differences and the role of education in cognitive ageing: analysis of two UK-based prospective cohort studies
- Effect of Depth of Sedation in Older Patients Undergoing Hip Fracture Repair on Postoperative Delirium: The STRIDE Randomized Clinical Trial
- Relationship Between Type 2 Diabetes Mellitus and Cognitive Change in a Multiethnic Elderly Cohort
- Mediterranean Diet and Risk of Dementia and Alzheimer's Disease in the EPIC-Spain Dementia Cohort Study
- Cambridge Neuropsychological Test Automated Battery (CANTAB): a factor analytic study of a large sample of normal elderly volunteers
- The aging hippocampus: cognitive, biochemical and structural findings
- UK Biobank data demonstrate long-term exposure to floods is a risk factor for incident dementia
- Hippocampal volume reduction in major depression