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Latent Classes of Neuropsychiatric Symptoms in NACC Controls and Conversion to Mild Cognitive Impairment or Dementia
Leoutsakos JM, Forrester SN, Lyketsos CG, Smith GS.. Journal of Alzheimer's disease : JAD, 2015-01-01
Topic: Risk, prevention and care in population studies
Background A number of studies have linked neuropsychiatric symptoms to increase risk of dementia. Objective To determine if risk of conversion to mild cognitive impairment or dementia among healthy controls varied as a function of their pattern of neuropsychiatric symptoms. Method We studied individuals in the National Alzheimer Coordinating Center dataset collected from 34 Alzheimer Disease Centers between 2005 and 2013.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Leoutsakos, J. M., Forrester, S. N., Lyketsos, C. G., & Smith, G. S. (2015). Latent Classes of Neuropsychiatric Symptoms in NACC Controls and Conversion to Mild Cognitive Impairment or Dementia. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-150421
Vancouver
Leoutsakos JM, Forrester SN, Lyketsos CG, Smith GS. Latent Classes of Neuropsychiatric Symptoms in NACC Controls and Conversion to Mild Cognitive Impairment or Dementia. Journal of Alzheimer's disease : JAD. 2015. doi:10.3233/jad-150421. PMID: 26402012.
BibTeX
@article{leoutsakos2015-26402012,
author = {Leoutsakos, J. M. and Forrester, S. N. and Lyketsos, C. G. and Smith, G. S.},
title = {{Latent Classes of Neuropsychiatric Symptoms in NACC Controls and Conversion to Mild Cognitive Impairment or Dementia}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2015},
doi = {10.3233/jad-150421},
pmid = {26402012},
url = {https://doi.org/10.3233/jad-150421}
}
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Key findings
- Objective To determine if risk of conversion to mild cognitive impairment or dementia among healthy controls varied as a function of their pattern of neuropsychiatric symptoms.
- Method We studied individuals in the National Alzheimer Coordinating Center dataset collected from 34 Alzheimer Disease Centers between 2005 and 2013.
- The analysis included 4,517 volunteers who were ≥60 years old, cognitively normal, and had complete Neuropsychiatric Inventory data at their baseline visit, and had at least one follow-up.
- We used latent class analysis to identify four classes based on patterns of NPI symptoms.
Why it matters
Among 4,517 cognitively normal volunteers aged 60 and older, this study examined whether different patterns of neuropsychiatric symptoms were linked to conversion to mild cognitive impairment or dementia. The researchers used data from 34 Alzheimer Disease Centers to see if symptom patterns in healthy controls predicted later decline.
Study details
- Participants4,517
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | 2 / 4 | Journal of Alzheimer s Disease: journal h-index 218 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 4,517 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 66 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.1 citations a year over 13 year(s) since 2015 |
| Impact for its field and year | 2 / 6 | Cited 2.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 2 / 4 | Cited 24 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Gwenn S. Smith: h-index 54 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Johns Hopkins University: institution h-index 2,306 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26402012) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
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