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74/100

✓ Peer-reviewed alzhub usefulness score 74 out of 100. Prevention and risk

Topic: Risk, prevention and care in population studies

Importance Vascular risk factors have been associated with cognitive decline. Results In total, 1516 cases of dementia (57.0% female and 34.9% black, with a mean [SD] age at visit 1 of 57.4 [5.2] years) were identified among 15 744 participants. Black race (hazard ratio [HR], 1.36; 95% CI, 1.21-1.54), older age (HR, 8.06; 95% CI, 6.69-9.72 for participants aged 60-66 years), lower educational attainment (HR, 1.61; 95% CI, 1.28-2.03 for less than a high school education), and APOE ε4 genotype (HR, 1.98; 95% CI, 1.78-2.21) were associated with increased risk of dementia, as were midlife smoking (HR, 1.41; 95% CI, 1.23-1.61), diabetes (HR, 1.77; 95% CI, 1.53-2.04), prehypertension (HR, 1.31; 95% CI, 1.14-1.51), and hypertension (HR, 1.39; 95% CI, 1.22-1.59). Conclusions and relevance Midlife vascular risk factors are associated with increased risk of dementia in black and white ARIC Study participants.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Gottesman, R. F., Albert, M. S., Alonso, A., Coker, L. H., Coresh, J., Davis, S. M., et al. (2017). Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort. JAMA neurology. https://doi.org/10.1001/jamaneurol.2017.1658

Vancouver

Gottesman RF, Albert MS, Alonso A, Coker LH, Coresh J, Davis SM, et al. Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort. JAMA neurology. 2017. doi:10.1001/jamaneurol.2017.1658. PMID: 28783817.

BibTeX

@article{gottesman2017-28783817,
  author  = {Gottesman, R. F. and Albert, M. S. and Alonso, A. and Coker, L. H. and Coresh, J. and Davis, S. M. and Deal, J. A. and McKhann, G. M. and others},
  title   = {{Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2017.1658},
  pmid    = {28783817},
  url     = {https://doi.org/10.1001/jamaneurol.2017.1658}
}

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Key findings

Importance Vascular risk factors have been associated with cognitive decline.
Results In total, 1516 cases of dementia (57.0% female and 34.9% black, with a mean [SD] age at visit 1 of 57.4 [5.2] years) were identified among 15 744 participants.
Black race (hazard ratio [HR], 1.36; 95% CI, 1.21-1.54), older age (HR, 8.06; 95% CI, 6.69-9.72 for participants aged 60-66 years), lower educational attainment (HR, 1.61; 95% CI, 1.28-2.03 for less than a high school education), and APOE ε4 genotype (HR, 1.98; 95% CI, 1.78-2.21) were associated with increased risk of dementia, as were midlife smoking (HR, 1.41; 95% CI, 1.23-1.61), diabetes (HR, 1.77; 95% CI, 1.53-2.04), prehypertension (HR, 1.31; 95% CI, 1.14-1.51), and hypertension (HR, 1.39; 95% CI, 1.22-1.59).
Conclusions and relevance Midlife vascular risk factors are associated with increased risk of dementia in black and white ARIC Study participants.

Why it matters

This cohort study found that midlife vascular risk factors including smoking, diabetes, prehypertension and hypertension were associated with increased risk of dementia in black and white participants. It reports risk associations only, not a treatment, cure or prevention.

New to this subject? Start with our plain-English guide: Prevention →

Study details

Study designprospective cohort
Participants744
Effect size27.1%; 72.9%; 57.0%
Evidence strengthModerate

How this study scored 74/100

Published in a leading specialty journal, and it is a prospective cohort study, followed forward from enrollment. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA neurology)
Journal's citation record	2 / 4	JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	7 / 12	A prospective cohort study, followed forward from enrollment
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2017 — within 10 year(s) of the newest study here
Sample size	2 / 4	744 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	6 / 7	Cited 630 times (OpenAlex, 2026-10-10)
Citations per year	5 / 5	57.3 citations a year over 11 year(s) since 2017
Impact for its field and year	5 / 6	Cited 34.6× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	4 / 6	Cited by 61 other studies in this library
Still being cited	4 / 4	Cited 223 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author David S. Knopman: h-index 188 (OpenAlex, whole career)
Institution's track record	2 / 3	Johns Hopkins University: institution h-index 2,306 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 8 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 28783817)
Free to read	0 / 2	Behind a paywall — scores zero
Total	74 / 100	—

What each of these 20 components measures, and what this score is not →

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