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51/100

✓ Peer-reviewed alzhub usefulness score 51 out of 100. Disparities

Topic: Risk, prevention and care in population studies

Plain-language summary

Background The association of central arterial stiffness and pressure pulsatility with mild cognitive impairment (MCI) and dementia is not well characterized in the population-based setting. Objective The aim of this study was to quantify the cross-sectional association of arterial stiffness and pressure pulsatility with MCI and dementia among 4,461 older white and black adults from the population-based Atherosclerosis Risk in Communities Study-Neurocognitive Study. Methods We used race-stratified multinomial logistic regression to evaluate associations of percentile cut points of carotid-femoral pulse wave velocity, central systolic blood pressure, central pulse pressure, and pulse pressure amplification with MCI and dementia versus no cognitive impairment. Results Among whites, those with carotid-femoral pulse wave velocity or central systolic blood pressure ≥75th percentile had a higher prevalence of MCI compared to participants 25th percentile (OR 1.65; (95% CI: 1.01, 2.70). Weaker associations were seen among black participants. Conclusion Higher arterial stiffness and pulsatility were associated with MCI and dementia in white participants. Longitudinal characterization of the observed associations is warranted to assess whether arterial stiffness and pressure pulsatility predict MCI and dementia among older adults.

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APA 7th

Meyer, M. L., Palta, P., Tanaka, H., Deal, J. A., Wright, J., Knopman, D. S., et al. (2017). Association of Central Arterial Stiffness and Pressure Pulsatility with Mild Cognitive Impairment and Dementia: The Atherosclerosis Risk in Communities Study-Neurocognitive Study (ARIC-NCS). Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-161041

Vancouver

Meyer ML, Palta P, Tanaka H, Deal JA, Wright J, Knopman DS, et al. Association of Central Arterial Stiffness and Pressure Pulsatility with Mild Cognitive Impairment and Dementia: The Atherosclerosis Risk in Communities Study-Neurocognitive Study (ARIC-NCS). Journal of Alzheimer's disease : JAD. 2017. doi:10.3233/jad-161041. PMID: 28222517.

BibTeX

@article{meyer2017-28222517,
  author  = {Meyer, M. L. and Palta, P. and Tanaka, H. and Deal, J. A. and Wright, J. and Knopman, D. S. and Griswold, M. E. and Mosley, T. H. and others},
  title   = {{Association of Central Arterial Stiffness and Pressure Pulsatility with Mild Cognitive Impairment and Dementia: The Atherosclerosis Risk in Communities Study-Neurocognitive Study (ARIC-NCS)}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2017},
  doi     = {10.3233/jad-161041},
  pmid    = {28222517},
  url     = {https://doi.org/10.3233/jad-161041}
}

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How to read this study

Design: this is a cross-sectional study. Everyone is measured once, so it cannot show which came first. Read it as a snapshot of how two things go together at one moment.
Size: the record gives no participant count. Look for one in the original before trusting a pattern.
Effect: the record reports “OR 1.65”. A statistically significant result can still be small in daily life.

What the evidence grade means here

This page is graded moderate. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Moderate means the abstract mentions a cohort, case-control or longitudinal design. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

Methods We used race-stratified multinomial logistic regression to evaluate associations of percentile cut points of carotid-femoral pulse wave velocity, central systolic blood pressure, central pulse pressure, and pulse pressure amplification with MCI and dementia versus no cognitive impairment.
Results Among whites, those with carotid-femoral pulse wave velocity or central systolic blood pressure ≥75th percentile had a higher prevalence of MCI compared to participants 25th percentile (OR 1.65; (95% CI: 1.01, 2.70).
Conclusion Higher arterial stiffness and pulsatility were associated with MCI and dementia in white participants.

Why it matters

Among white participants, higher arterial stiffness and pressure pulsatility were associated with mild cognitive impairment and dementia, with weaker associations among black participants. The study was cross-sectional, so it cannot show whether these factors predict or cause cognitive impairment.

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Study details

Study designcross-sectional
Effect sizeOR 1.65
Evidence strengthModerate

How this study scored 51/100

Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for sample size, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD)
Journal's citation record	2 / 4	Journal of Alzheimer s Disease: journal h-index 218 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2017 — within 10 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 70 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	6.4 citations a year over 11 year(s) since 2017
Impact for its field and year	3 / 6	Cited 5.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 14 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Gerardo M HEISS: h-index 120 (OpenAlex, whole career)
Institution's track record	2 / 3	Johns Hopkins University: institution h-index 2,306 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 6 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 28222517)
Free to read	0 / 2	Behind a paywall — scores zero
Total	51 / 100	—

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