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Delirium superimposed on dementia: clinical implications, challenges, and management strategies
Pemilda Dian Catur Ayu Wisnu Putri, Margarita Maria Maramis. Asian Journal of Gerontology and Geriatrics, 2025-12-23
Topic: Risk, prevention and care in population studies
Delirium superimposed on dementia (DSD) is a frequent but underrecognised condition that complicates care in older adults.Although delirium and dementia share overlapping features, their clinical courses and management differ substantially.Failure to distinguish between the two can delay appropriate treatment and worsen outcomes, including prolonged hospitalisation, accelerated cognitive decline, and increased mortality.This review outlines the clinical features, challenges, and management strategies for DSD, highlighting the importance of recognising acute changes in behaviour and cognition.We emphasise the role of early identification, nonpharmacological interventions, and cautious medication use in patients with underlying cognitive impairment.The emerging view of delirium as a potential contributor to neurodegeneration was discussed, highlighting the importance of post-delirium follow-up and long-term cognitive monitoring.Increased awareness and the use of a structured, multidisciplinary approach enable clinicians to better manage DSD and reduce its long-term impacts on patients and caregivers.
Key findings
- Delirium superimposed on dementia (DSD) is a frequent but underrecognised condition that complicates care in older adults.Although delirium and dementia share overlapping features, their clinical courses and management differ substantially.Failure to distinguish between the two can delay appropriate treatment and worsen outcomes, including prolonged hospitalisation, accelerated cognitive decline, and increased mortality.This review outlines the clinical features, challenges, and management strategies for DSD, highlighting the importance of recognising acute changes in behaviour and cognition.We emphasise the role of early identification, nonpharmacological interventions, and cautious medication use in patients with underlying cognitive impairment.The emerging view of delirium as a potential contributor to neurodegeneration was discussed, highlighting the importance of post-delirium follow-up and long-term cognitive monitoring.Increased awareness and the use of a structured, multidisciplinary approach enable clinicians to better manage DSD and reduce its long-term impacts on patients and caregivers.
Why it matters
This review outlines that delirium superimposed on dementia is frequent but underrecognised, and that failure to distinguish between the two can delay treatment and worsen outcomes. It emphasizes early identification, nonpharmacological interventions, and cautious medication use, and discusses delirium as a potential contributor to neurodegeneration.
Study details
- Evidence strengthLow
How this study scored 28/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Asian Journal of Gerontology and Geriatrics) |
| Journal's citation record | 0 / 4 | Asian Journal of Gerontology and Geriatrics: journal h-index 9 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 1 / 6 | Cited 0.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Margarita Maria Maramis: h-index 13 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Universitas Airlangga: institution h-index 163 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Total | 28 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.12809/ajgg-2025-741-ra
- Original source →
- Free full text: Asian Journal of Gerontology and Geriatrics →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Putri, P. D. C. A. W., & Maramis, M. M. (2025). Delirium superimposed on dementia: clinical implications, challenges, and management strategies. Asian Journal of Gerontology and Geriatrics. https://doi.org/10.12809/ajgg-2025-741-ra
Vancouver
Putri PDCAW, Maramis MM. Delirium superimposed on dementia: clinical implications, challenges, and management strategies. Asian Journal of Gerontology and Geriatrics. 2025. doi:10.12809/ajgg-2025-741-ra.
BibTeX
@article{putri2025-712e7117,
author = {Putri, Pemilda Dian Catur Ayu Wisnu and Maramis, Margarita Maria},
title = {{Delirium superimposed on dementia: clinical implications, challenges, and management strategies}},
journal = {Asian Journal of Gerontology and Geriatrics},
year = {2025},
doi = {10.12809/ajgg-2025-741-ra},
url = {https://doi.org/10.12809/ajgg-2025-741-ra}
}