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Symptoms of rapid eye movement sleep behavior disorder are associated with cholinergic denervation in Parkinson disease
Kotagal V, Albin RL, Müller ML, Koeppe RA, Chervin RD, Frey KA, Bohnen NI.. Annals of neurology, 2012-04-01
Topic: Brain proteins, microglia and lab models
Objective Rapid eye movement sleep behavior disorder (RBD) is common in Parkinson disease (PD), but its relationship to the varied neurotransmitter deficits of PD and prognostic significance remain incompletely understood. RBD and cholinergic system degeneration are identified independently as risk factors for cognitive impairment in PD. We aimed to assess the association between cholinergic denervation and symptoms of RBD in PD patients without dementia.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Kotagal, V., Albin, R. L., Müller, M. L., Koeppe, R. A., Chervin, R. D., Frey, K. A., et al. (2012). Symptoms of rapid eye movement sleep behavior disorder are associated with cholinergic denervation in Parkinson disease. Annals of neurology. https://doi.org/10.1002/ana.22691
Vancouver
Kotagal V, Albin RL, Müller ML, Koeppe RA, Chervin RD, Frey KA, et al. Symptoms of rapid eye movement sleep behavior disorder are associated with cholinergic denervation in Parkinson disease. Annals of neurology. 2012. doi:10.1002/ana.22691. PMID: 22522445.
BibTeX
@article{kotagal2012-22522445,
author = {Kotagal, V. and Albin, R. L. and Müller, M. L. and Koeppe, R. A. and Chervin, R. D. and Frey, K. A. and Bohnen, N. I.},
title = {{Symptoms of rapid eye movement sleep behavior disorder are associated with cholinergic denervation in Parkinson disease}},
journal = {Annals of neurology},
year = {2012},
doi = {10.1002/ana.22691},
pmid = {22522445},
url = {https://doi.org/10.1002/ana.22691}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- RBD and cholinergic system degeneration are identified independently as risk factors for cognitive impairment in PD.
- We aimed to assess the association between cholinergic denervation and symptoms of RBD in PD patients without dementia.
- Methods Eighty subjects with PD without dementia (age, 64.6 ± 7.0 years; range, 50-82 years; 60 males, 20 females; mean Montreal Cognitive Assessment Test [MoCA] score, 26.2 ± 2.1; range 21-30) underwent clinical assessment, neuropsychological testing, and [(11)C]methylpiperidyl propionate acetylcholinesterase and [(11)C]dihydrotetrabenazine (DTBZ) vesicular monoamine transporter type 2 positron emission tomography (PET) imaging.
- (11)C3-Amino-4-(2-dimethylaminomethyl-phenylsulfaryl)-benzonitrile (DASB) serotonin transporter PET imaging was performed in a subset of 35 subjects.
Why it matters
In people with Parkinson disease without dementia, symptoms of REM sleep behavior disorder were linked to loss of the brain chemical acetylcholine. This does not show a treatment or cure, but it may help explain why some of these patients are more likely to develop thinking problems.
Study details
- Participants35
- Effect size33.8%
- Evidence strengthLow
How this study scored 54/100
Published in a leading specialty journal. Scored zero for study design and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Annals of neurology) |
| Journal's citation record | 3 / 4 | Annals of Neurology: journal h-index 437 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2012 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 35 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 253 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 15.8 citations a year over 16 year(s) since 2012 |
| Impact for its field and year | 4 / 6 | Cited 8.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 2 / 4 | Cited 34 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Nicolaas Ida Bohnen: h-index 68 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Michigan: institution h-index 2,240 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 22522445) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 54 / 100 | — |
What each of these 20 components measures, and what this score is not →
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