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Reference Tissue-Based Kinetic Evaluation of 18F-AV-1451 for Tau Imaging
Baker SL, Lockhart SN, Price JC, He M, Huesman RH, Schonhaut D, Faria J, Rabinovici G et al.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016-09-01
Topic: Plasma and spinal-fluid biomarkers
The goal of this paper was to evaluate the in vivo kinetics of the novel tau-specific PET radioligand 18 F-AV-1451 in cognitively healthy control (HC) and Alzheimer disease (AD) subjects, using reference region analyses. Methods 18 F-AV-1451 PET imaging was performed on 43 subjects (5 young HCs, 23 older HCs, and 15 AD subjects). Data were collected from 0 to 150 min after injection, with a break from 100 to 120 min. T1-weighted MR images were segmented using FreeSurfer to create 14 bilateral regions of interest (ROIs). In all analyses, cerebellar gray matter was used as the reference region. Nondisplaceable binding potentials (BP ND s) were calculated using the simplified reference tissue model (SRTM) and SRTM2; the Logan graphical analysis distribution volume ratio (DVR) was calculated for 30-150 min (DVR30-150). These measurements were compared with each other and used as reference standards for defining an appropriate 20-min window for the SUV ratio (SUVR). Pearson correlations were used to compare the reference standards to 20-min SUVRs (start times varied from 30 to 130 min), for all values, for ROIs with low 18 F-AV-1451 binding (lROIs, mean of BP ND + 1 and DVR30-150 < 1.5), and for ROIs with high 18 F-AV-1451 binding (hROIs, mean of BP ND + 1 and DVR30-150 > 1.5). Results SRTM2 BP ND + 1 and DVR30-150 were in good agreement. Both were in agreement with SRTM BP ND + 1 for lROIs but were greater than SRTM BP ND + 1 for hROIs, resulting in a nonlinear relationship. hROI SUVRs increased from 80-100 to 120-140 min by 0.24 ± 0.15. The SUVR time interval resulting in the highest correlation and slope closest to 1 relative to the reference standards for all values was 120-140 min for hROIs, 60-80 min for lROIs, and 80-100 min for lROIs and hROIs. There was minimal difference between methods when statistical significance between ADs and HCs was calculated. Conclusion Despite later time periods providing better agreement between reference standards and SUVRs for hROIs, a good compromise for studying lROIs and hROIs is SUVR80-100. The lack of SUVR plateau for hROIs highlights the importance of precise acquisition time for longitudinal assessment.
Key findings
- These measurements were compared with each other and used as reference standards for defining an appropriate 20-min window for the SUV ratio (SUVR).
- Results SRTM2 BP ND + 1 and DVR30-150 were in good agreement.
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Study details
- Study designlongitudinal study
- Participants43
- Evidence strengthModerate
How this study scored 60/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 35 of the 58 points we could judge it on, which is 60 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of nuclear medicine : official publication, Society of Nuclear Medicine) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 43 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27587706) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 35 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 35 of the 58 points we could judge it on is 60 out of 100. |
| Total | 60 / 100 | — |
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APA 7th
Baker, S. L., Lockhart, S. N., Price, J. C., He, M., Huesman, R. H., Schonhaut, D., et al. (2017). Reference Tissue-Based Kinetic Evaluation of 18F-AV-1451 for Tau Imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. https://doi.org/10.2967/jnumed.116.175273
Vancouver
Baker SL, Lockhart SN, Price JC, He M, Huesman RH, Schonhaut D, et al. Reference Tissue-Based Kinetic Evaluation of 18F-AV-1451 for Tau Imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2017. doi:10.2967/jnumed.116.175273. PMID: 27587706.
BibTeX
@article{baker2017-27587706,
author = {Baker, S. L. and Lockhart, S. N. and Price, J. C. and He, M. and Huesman, R. H. and Schonhaut, D. and Faria, J. and Rabinovici, G. and others},
title = {{Reference Tissue-Based Kinetic Evaluation of 18F-AV-1451 for Tau Imaging}},
journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
year = {2017},
doi = {10.2967/jnumed.116.175273},
pmid = {27587706},
url = {https://doi.org/10.2967/jnumed.116.175273}
}
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