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Plasma p-tau181, neurofilament light chain and association with cognition in Parkinson’s disease
Lucia Batzu, Silvia Rota, Abdul Hye, Amanda Heslegrave, Dhaval Trivedi, Lucy L. Gibson, Chloe Farrell, Pavlos Zinzalias et al.. npj Parkinson's Disease, 2022-11-12
Topic: Plasma and spinal-fluid biomarkers
Early identification of cognitive impairment in Parkinson’s disease (PD) has important clinical and research implications. The aim of our study was to investigate the role of plasma tau phosphorylated at amino acid 181 (p-tau181) and plasma neurofilament light chain (NfL) as biomarkers of cognition in PD. Baseline concentrations of plasma p-tau181 and NfL were measured in a cohort of 136 patients with PD and 63 healthy controls (HC). Forty-seven PD patients were followed up for up to 2 years. Cross-sectional and longitudinal associations between baseline plasma biomarkers and cognitive progression were investigated using linear regression and linear mixed effects models. At baseline, plasma p-tau181 concentration was significantly higher in PD subjects compared with HC ( p = 0.026). In PD patients, higher plasma NfL was associated with lower MMSE score at baseline, after adjusting for age, sex and education ( p = 0.027). Baseline plasma NfL also predicted MMSE decline over time in the PD group ( p = 0.020). No significant association between plasma p-tau181 concentration and baseline or longitudinal cognitive performance was found. While the role of p-tau181 as a diagnostic biomarker for PD and its relationship with cognition need further elucidation, plasma NfL may serve as a feasible, non-invasive biomarker of cognitive progression in PD.
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APA 7th
Batzu, L., Rota, S., Hye, A., Heslegrave, A., Trivedi, D., Gibson, L. L., et al. (2022). Plasma p-tau181, neurofilament light chain and association with cognition in Parkinson’s disease. npj Parkinson's Disease. https://doi.org/10.1038/s41531-022-00384-x
Vancouver
Batzu L, Rota S, Hye A, Heslegrave A, Trivedi D, Gibson LL, et al. Plasma p-tau181, neurofilament light chain and association with cognition in Parkinson’s disease. npj Parkinson's Disease. 2022. doi:10.1038/s41531-022-00384-x.
BibTeX
@article{batzu2022-c7b91a06,
author = {Batzu, Lucia and Rota, Silvia and Hye, Abdul and Heslegrave, Amanda and Trivedi, Dhaval and Gibson, Lucy L. and Farrell, Chloe and Zinzalias, Pavlos and others},
title = {{Plasma p-tau181, neurofilament light chain and association with cognition in Parkinson’s disease}},
journal = {npj Parkinson's Disease},
year = {2022},
doi = {10.1038/s41531-022-00384-x},
url = {https://doi.org/10.1038/s41531-022-00384-x}
}
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Key findings
- At baseline, plasma p-tau181 concentration was significantly higher in PD subjects compared with HC ( p = 0.026).
- In PD patients, higher plasma NfL was associated with lower MMSE score at baseline, after adjusting for age, sex and education ( p = 0.027).
- No significant association between plasma p-tau181 concentration and baseline or longitudinal cognitive performance was found.
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Study details
- Study designcross-sectional
- Participants136
- Evidence strengthModerate
How this study scored 59/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 33 of the 56 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (npj Parkinson's Disease) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 136 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 33 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 33 of the 56 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
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