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[Radiological Identification and Evaluation of Amyloid-Related Imaging Abnormalities in Alzheimer's Disease]
Xiyue Yang, Wanting Li, Xinglong Yang, Qin Chen, Hongxia Li, Su Lyu, Na Hu. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2024-11-20
Topic: Plasma and spinal-fluid biomarkers
Amyloid-related imaging abnormalities (ARIA), intracranial signal abnormalities observed in magnetic resonance imaging (MRI), represent one of the main adverse events associated with treating Alzheimer's disease (AD) with anti-amyloid-β (anti-Aβ) monoclonal antibodies. In severe cases, patients' lives may be threatened. As the first anti-Aβ antibody was approved for use in China, clinical departments are now confronted with an increased likelihood of encountering ARIA in real-world scenarios. Accurate pre-treatment risk assessment, timely identification during medication, and severity evaluation of ARIA are of great significance in guiding clinical decisions. The identification and assessment of ARIA can be conducted from two perspectives-imaging and clinical symptoms. This article focuses on imaging. We reviewed the pathophysiological mechanisms, epidemiological and clinical characteristics, and imaging protocols and assessment of ARIA. We also stated at the end of the review that most current research data on ARIA came from clinical drug trials involving Caucasian populations, and that there was a lack of treatment experience in the real-world application of anti-Aβ monoclonal antibodies in Chinese populations. Many issues concerning pre-treatment risk assessment still need to be explored. Additionally, whether there are other clinical factors and imaging indicators that can help predict drug risks, and whether using different imaging protocols can help make a difference in patient management in the real world all require further investigation.
Key findings
- Amyloid-related imaging abnormalities (ARIA), intracranial signal abnormalities observed in magnetic resonance imaging (MRI), represent one of the main adverse events associated with treating Alzheimer's disease (AD) with anti-amyloid-β (anti-Aβ) monoclonal antibodies.
- As the first anti-Aβ antibody was approved for use in China, clinical departments are now confronted with an increased likelihood of encountering ARIA in real-world scenarios.
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Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 24 of the 56 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39990823) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 24 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 24 of the 56 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Yang, X., Li, W., Yang, X., Chen, Q., Li, H., Lyu, S., et al. (2024). [Radiological Identification and Evaluation of Amyloid-Related Imaging Abnormalities in Alzheimer's Disease]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. https://doi.org/10.12182/20241160201
Vancouver
Yang X, Li W, Yang X, Chen Q, Li H, Lyu S, et al. [Radiological Identification and Evaluation of Amyloid-Related Imaging Abnormalities in Alzheimer's Disease]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2024. doi:10.12182/20241160201. PMID: 39990823.
BibTeX
@article{yang2024-39990823,
author = {Yang, Xiyue and Li, Wanting and Yang, Xinglong and Chen, Qin and Li, Hongxia and Lyu, Su and Hu, Na},
title = {{[Radiological Identification and Evaluation of Amyloid-Related Imaging Abnormalities in Alzheimer's Disease]}},
journal = {Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition},
year = {2024},
doi = {10.12182/20241160201},
pmid = {39990823},
url = {https://doi.org/10.12182/20241160201}
}
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