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Vascular and neurodegenerative contributions to cognitive decline and multidomain progression in de novo Parkinsons disease
Moqadam, R.; Azizi, H.; Raeesi, S.; Zeighami, Y.; Dadar, M.. medRxiv (preprint), 2026-09-11
Topic: Brain proteins, microglia and lab models
Greater baseline WMH burden was associated with differential longitudinal progression in converters across eleven clinical outcomes, including cognition, gait, and functional independence (all q<0.05). C_LIO_LIWMH burden was selectively associated with neuropsychiatric symptoms and functional independence C_LIO_LIVascular and neurodegenerative markers provided complementary prognostic information.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Moqadam, R., Azizi, H., Raeesi, S., Zeighami, Y., & Dadar, M. (2026). Vascular and neurodegenerative contributions to cognitive decline and multidomain progression in de novo Parkinsons disease. medRxiv (preprint). https://doi.org/10.64898/2026.09.09.26362673
Vancouver
Moqadam R, Azizi H, Raeesi S, Zeighami Y, Dadar M. Vascular and neurodegenerative contributions to cognitive decline and multidomain progression in de novo Parkinsons disease. medRxiv (preprint). 2026. doi:10.64898/2026.09.09.26362673.
BibTeX
@article{moqadam2026-8c3654ac,
author = {Moqadam, R. and Azizi, H. and Raeesi, S. and Zeighami, Y. and Dadar, M.},
title = {{Vascular and neurodegenerative contributions to cognitive decline and multidomain progression in de novo Parkinsons disease}},
journal = {medRxiv (preprint)},
year = {2026},
doi = {10.64898/2026.09.09.26362673},
url = {https://doi.org/10.64898/2026.09.09.26362673}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Greater baseline WMH burden was associated with differential longitudinal progression in converters across eleven clinical outcomes, including cognition, gait, and functional independence (all q<0.05).
- C_LIO_LIWMH burden was selectively associated with neuropsychiatric symptoms and functional independence C_LIO_LIVascular and neurodegenerative markers provided complementary prognostic information.
Why it matters
In people with newly diagnosed Parkinson's disease, greater baseline white matter hyperintensity burden was linked to different progression in cognition, gait, and functional independence. It is about prognosis in Parkinson's disease, not about treating, curing, or preventing Alzheimer's disease.
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Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 31 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on impact for its field and year, so that was left out: it earned 29 of the 94 points we could judge it on, which is 31 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (medRxiv (preprint)) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Mahsa Dadar: h-index 40 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | McGill University: institution h-index 1,373 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Points | 29 / 94 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 29 of the 94 points we could judge it on is 31 out of 100. |
| Total | 31 / 100 | Capped to 16 because this is not a peer-reviewed article. |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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