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52/100

✓ Peer-reviewed alzhub usefulness score 52 out of 100. Inflammation and the immune system

Topic: Brain proteins, microglia and lab models

Plain-language summary

Objectives Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are collectively called as Lewy body dementia (LBD). Despite the urgent clinical need, there is no reliable protein biomarker for LBD. Hence, we conducted the first comprehensive systematic review of all Differentially Abundant Proteins (DAP) in all tissues from people with LBD for advancing our understanding of LBD molecular pathology that is essential for facilitating discovery of novel diagnostic biomarkers and therapeutic targets for LBD. Methods We identified eligible studies by comprehensively searching five databases and grey literature (PROSPERO protocol:CRD42020218889). We completed quality assessment and extracted relevant data. We completed narrative synthesis and appropriate meta-analyses. We analysed functional implications of all reported DAP using DAVID tools. Results We screened 11,006 articles and identified 193 eligible studies. 305 DAP were reported and 16 were replicated in DLB. 37 DAP were reported and three were replicated in PDD. Our meta-analyses confirmed six DAP (TAU, SYUA, NFL, CHI3L1, GFAP, CLAT) in DLB, and three DAP (TAU, SYUA, NFL) in PDD. There was no replicated blood-based DAP in DLB or PDD. The reported DAP may contribute to LBD pathology by impacting misfolded protein clearance, dopamine neurotransmission, apoptosis, neuroinflammation, synaptic plasticity and extracellular vesicles. Conclusion Our meta-analyses confirmed significantly lower CSF TAU levels in DLB and CSF SYUA levels in PDD, when compared to Alzheimer's disease. Our findings indicate promising diagnostic biomarkers for LBD and may help prioritising molecular pathways for therapeutic target discovery. We highlight ten future research priorities based on our findings.

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APA 7th

Farr, L. M., Thorpe, N., Brinda, E. M., Albalushi, N., Sohail, M., & Rajkumar, A. P. (2025). Systematic review of differentially abundant proteins in people with Lewy body dementia. Acta neuropsychiatrica. https://doi.org/10.1017/neu.2025.15

Vancouver

Farr LM, Thorpe N, Brinda EM, Albalushi N, Sohail M, Rajkumar AP. Systematic review of differentially abundant proteins in people with Lewy body dementia. Acta neuropsychiatrica. 2025. doi:10.1017/neu.2025.15. PMID: 40143552.

BibTeX

@article{farr2025-40143552,
  author  = {Farr, L. M. and Thorpe, N. and Brinda, E. M. and Albalushi, N. and Sohail, M. and Rajkumar, A. P.},
  title   = {{Systematic review of differentially abundant proteins in people with Lewy body dementia}},
  journal = {Acta neuropsychiatrica},
  year    = {2025},
  doi     = {10.1017/neu.2025.15},
  pmid    = {40143552},
  url     = {https://doi.org/10.1017/neu.2025.15}
}

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How to read this study

Design: this is a pooled review. It combines earlier studies, so it is only as good as the studies it pools. Check how many were included, whether they were similar enough to combine, and whether the authors report inconsistency between them.
Size: the record gives no participant count. Look for one in the original before trusting a pattern.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded high. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. High means the abstract mentions a randomized design, a meta-analysis or a systematic review. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

Results We screened 11,006 articles and identified 193 eligible studies. 305 DAP were reported and 16 were replicated in DLB. 37 DAP were reported and three were replicated in PDD.
Conclusion Our meta-analyses confirmed significantly lower CSF TAU levels in DLB and CSF SYUA levels in PDD, when compared to Alzheimer's disease.
Our findings indicate promising diagnostic biomarkers for LBD and may help prioritising molecular pathways for therapeutic target discovery.
We highlight ten future research priorities based on our findings.

Why it matters

Screening 11,006 articles, this review found 193 studies of proteins that differ in people with Lewy body dementia. Meta-analyses confirmed six such proteins in dementia with Lewy bodies (TAU, SYUA, NFL, CHI3L1, GFAP, CLAT), and found lower spinal fluid TAU in that condition than in Alzheimer's, though no blood-based protein was replicated. The authors see promising diagnostic markers that could help tell Lewy body dementia apart and guide future drug target research.

Study details

Study designsystematic review
Evidence strengthHigh

How this study scored 52/100

Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. Scored zero for sample size, effect reported and studied in people because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Acta neuropsychiatrica)
Journal's citation record	0 / 4	Acta Neuropsychiatrica: journal h-index 59 (OpenAlex, 2026-10-29)
Study design	12 / 12	A systematic review of all the studies on the question
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	A review of other studies — randomization is not credited here
Times cited	1 / 7	Cited 4 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.3 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 2 other studies in this library
Still being cited	1 / 4	Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Anto Praveen Rajkumar: h-index 31 (OpenAlex, whole career)
Institution's track record	1 / 3	University of Nottingham: institution h-index 879 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40143552)
Free to read	2 / 2	Free to read
Total	52 / 100	—

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