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Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research
Jung ES, Choi H, Mook-Jung I.. Molecular neurodegeneration, 2025-03-27
Topic: Brain proteins, microglia and lab models
Alzheimer's disease (AD) involves a dynamic interaction between neuroinflammation and metabolic dysregulation, where microglia play a central role. These immune cells undergo metabolic reprogramming in response to AD-related pathology, with key genes such as TREM2, APOE, and HIF-1α orchestrating these processes. Microglial metabolism adapts to environmental stimuli, shifting between oxidative phosphorylation and glycolysis.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Jung, E. S., Choi, H., & Mook-Jung, I. (2025). Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research. Molecular neurodegeneration. https://doi.org/10.1186/s13024-025-00825-0
Vancouver
Jung ES, Choi H, Mook-Jung I. Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research. Molecular neurodegeneration. 2025. doi:10.1186/s13024-025-00825-0. PMID: 40149001.
BibTeX
@article{jung2025-40149001,
author = {Jung, E. S. and Choi, H. and Mook-Jung, I.},
title = {{Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research}},
journal = {Molecular neurodegeneration},
year = {2025},
doi = {10.1186/s13024-025-00825-0},
pmid = {40149001},
url = {https://doi.org/10.1186/s13024-025-00825-0}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- These immune cells undergo metabolic reprogramming in response to AD-related pathology, with key genes such as TREM2, APOE, and HIF-1α orchestrating these processes.
- Microglial metabolism adapts to environmental stimuli, shifting between oxidative phosphorylation and glycolysis.
- Hexokinase-2 facilitates glycolytic flux, while AMPK acts as an energy sensor, coordinating lipid and glucose metabolism.
- TREM2 and APOE regulate microglial lipid homeostasis, influencing Aβ clearance and immune responses.
Why it matters
This review describes how microglia change their metabolism in Alzheimer's disease, with genes such as TREM2, APOE and HIF-1α involved. It reports no treatment, cure or prevention; it only outlines a research direction.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Molecular neurodegeneration) |
| Journal's citation record | 2 / 4 | Molecular Neurodegeneration: journal h-index 164 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 108 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 36.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 5 / 6 | Cited 32.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 108 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Inhee Mook‐Jung: h-index 71 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Seoul National University: institution h-index 1,053 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40149001) |
| Free to read | 2 / 2 | Free to read |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/s13024-025-00825-0
- PubMed: 40149001
- Original source →
- Free full text: Molecular Neurodegeneration →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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