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The Alzheimer amyloid precursor protein maps to human chromosome 21 bands q21.105-q21.05
Korenberg JR, Pulst SM, Neve RL, West R.. Genomics, 1989-07-01
Topic: Amyloid, tau and blood-test diagnosis
The Alzheimer amyloid protein precursor (APP) has previously been localized to human chromosome 21q11.2-q21. We have refined the regional localization to a small region including chromosome bands 21q21.105-q21.05 by using quantitative Southern blot analysis of cell lines aneuploid for parts of chromosome 21. Our findings exclude the APP gene from the minimal region producing the classical phenotypic features of Down syndrome. This further narrowing of the APP location will help in identifying the physical location of the gene causing familial Alzheimer disease.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Korenberg, JR., Pulst, S. M., Neve, R. L., & West, R. (1989). The Alzheimer amyloid precursor protein maps to human chromosome 21 bands q21.105-q21.05. Genomics. https://doi.org/10.1016/0888-7543(89)90095-5
Vancouver
Korenberg JR, Pulst SM, Neve RL, West R. The Alzheimer amyloid precursor protein maps to human chromosome 21 bands q21.105-q21.05. Genomics. 1989. doi:10.1016/0888-7543(89)90095-5. PMID: 2527801.
BibTeX
@article{korenberg1989-2527801,
author = {Korenberg, JR. and Pulst, S. M. and Neve, R. L. and West, R.},
title = {{The Alzheimer amyloid precursor protein maps to human chromosome 21 bands q21.105-q21.05}},
journal = {Genomics},
year = {1989},
doi = {10.1016/0888-7543(89)90095-5},
pmid = {2527801},
url = {https://doi.org/10.1016/0888-7543(89)90095-5}
}
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Key findings
- Our findings exclude the APP gene from the minimal region producing the classical phenotypic features of Down syndrome.
Why it matters
This study narrowed the location of the amyloid precursor protein gene on chromosome 21 and excluded it from the region causing classic Down syndrome features. It is basic mapping and does not test any treatment.
Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 37 of the 96 points we could judge it on, which is 39 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Genomics) |
| Journal's citation record | 2 / 4 | Genomics: journal h-index 216 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1989 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 57 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.5 citations a year over 39 year(s) since 1989 |
| Impact for its field and year | 2 / 6 | Cited 2.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 1 / 4 | Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | OpenAlex's profile for last-listed author R. J. West holds only 3 work(s), too few to judge a track record — left out of this score |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 2527801) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 37 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 37 of the 96 points we could judge it on is 39 out of 100. |
| Total | 39 / 100 | — |
What each of these 20 components measures, and what this score is not →
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