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Olfactory bulb lesions in Alzheimer's disease
Struble RG, Clark HB.. Neurobiology of aging, 1992-07-01
Topic: Amyloid, tau and blood-test diagnosis
The olfactory bulb (OB), with its comparatively simple and well-delineated connectivity, presents an interesting system for examining cell-specific pathology in neurologic degenerative disorders such as Alzheimer's disease (AD). We have found that in AD the large, efferently projecting neurons (mitral cells) of the OB degenerate, typically without classical Alzheimer neurofibrillary changes. In some cases, with less severe neocortical pathology, the terminal arborizations of olfactory nerve appear hyperplastic and are associated with focal accumulations of A-4 (beta-amyloid) immunoreactivity that are not detectable by standard amyloid stains. These abnormalities may represent a pathologic manifestation of normally occurring plasticity in the olfactory system.
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APA 7th
Struble, R. G., & Clark, H. B. (1992). Olfactory bulb lesions in Alzheimer's disease. Neurobiology of aging. https://doi.org/10.1016/0197-4580(92)90074-8
Vancouver
Struble RG, Clark HB. Olfactory bulb lesions in Alzheimer's disease. Neurobiology of aging. 1992. doi:10.1016/0197-4580(92)90074-8. PMID: 1508297.
BibTeX
@article{struble1992-1508297,
author = {Struble, R. G. and Clark, H. B.},
title = {{Olfactory bulb lesions in Alzheimer's disease}},
journal = {Neurobiology of aging},
year = {1992},
doi = {10.1016/0197-4580(92)90074-8},
pmid = {1508297},
url = {https://doi.org/10.1016/0197-4580(92)90074-8}
}
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Key findings
- In some cases, with less severe neocortical pathology, the terminal arborizations of olfactory nerve appear hyperplastic and are associated with focal accumulations of A-4 (beta-amyloid) immunoreactivity that are not detectable by standard amyloid stains.
Why it matters
In Alzheimer disease, the large efferently projecting mitral cells of the olfactory bulb were found to degenerate, and in some cases olfactory nerve terminals showed hyperplasia with focal accumulations of beta-amyloid immunoreactivity. This is a pathological description of the olfactory bulb in Alzheimer disease, not a treatment, cure or prevention.
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Study details
- Evidence strengthLow
How this study scored 36/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of aging) |
| Journal's citation record | 3 / 4 | Neurobiology of Aging: journal h-index 263 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1992 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 69 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.9 citations a year over 36 year(s) since 1992 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author H. Brent Clark: h-index 19 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | SIU Medicine: institution h-index 307 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 1508297) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 36 / 100 | — |
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