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Immunoglobulin G subclasses in older persons with Down syndrome
Mehta PD, Dalton AJ, Mehta SP, Percy ME, Sersen EA, Wisniewski HM.. Journal of the neurological sciences, 1993-07-01
Topic: Brain proteins, microglia and lab models
IgG subclasses were measured in sera from 33 persons with Down syndrome (DS) (mean age 55 +/- 7 years) and 33 age- and sex-matched control individuals using a mouse monoclonal antibody based sandwich enzyme linked immunosorbent assay. Significantly higher levels of IgG1 and IgG3 and lower levels of IgG2 and IgG4 subclasses were found in the DS group compared to the control individuals. The higher levels of IgG1 and IgG3 subclasses found in DS persons were consistent with those seen in patients with autoimmune diseases and chronic viral infections; the lower levels of IgG2 and IgG4 subclasses were consistent with those seen in patients with recurrent infections. Our findings are similar to those reported in children with DS. We speculate that the subclass levels may have little or no relationship to the development of brain lesions typical of Alzheimer disease in older persons with DS. There were no significant differences between the levels of IgG subclasses of persons with DS showing signs of dementia of the Alzheimer type compared to those without such manifestations.
Key findings
- Significantly higher levels of IgG1 and IgG3 and lower levels of IgG2 and IgG4 subclasses were found in the DS group compared to the control individuals.
- Our findings are similar to those reported in children with DS.
- There were no significant differences between the levels of IgG subclasses of persons with DS showing signs of dementia of the Alzheimer type compared to those without such manifestations.
Why it matters
In 33 older people with Down syndrome, levels of IgG1 and IgG3 were higher and IgG2 and IgG4 lower than in matched controls, a pattern seen in autoimmune diseases and chronic infections. There were no significant differences in IgG subclass levels between those with signs of Alzheimer-type dementia and those without, and the authors speculate these levels may have little or no relationship to the brain lesions of Alzheimer's disease.
Study details
- Participants33
- Evidence strengthLow
How this study scored 35/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of the neurological sciences) |
| Journal's citation record | 2 / 4 | Journal of the Neurological Sciences: journal h-index 233 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1993 — older than 20 years, still counted |
| Sample size | 1 / 4 | 33 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 8 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.2 citations a year over 35 year(s) since 1993 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Henryk M. Wisniewski: h-index 40 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Toronto: institution h-index 1,923 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 8410055) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 35 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Mehta, P. D., Dalton, A. J., Mehta, S. P., Percy, M. E., Sersen, E. A., & Wisniewski, H. M. (1993). Immunoglobulin G subclasses in older persons with Down syndrome. Journal of the neurological sciences. https://doi.org/10.1016/0022-510x(93)90172-u
Vancouver
Mehta PD, Dalton AJ, Mehta SP, Percy ME, Sersen EA, Wisniewski HM. Immunoglobulin G subclasses in older persons with Down syndrome. Journal of the neurological sciences. 1993. doi:10.1016/0022-510x(93)90172-u. PMID: 8410055.
BibTeX
@article{mehta1993-8410055,
author = {Mehta, P. D. and Dalton, A. J. and Mehta, S. P. and Percy, M. E. and Sersen, E. A. and Wisniewski, H. M.},
title = {{Immunoglobulin G subclasses in older persons with Down syndrome}},
journal = {Journal of the neurological sciences},
year = {1993},
doi = {10.1016/0022-510x(93)90172-u},
pmid = {8410055},
url = {https://doi.org/10.1016/0022-510x(93)90172-u}
}
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