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A double-blind placebo-controlled study of clomipramine in depressed patients with Alzheimer's disease
G Petracca, A Tesón, E Chemerinski, R Leiguarda, S E Starkstein. The Journal of neuropsychiatry and clinical neurosciences, 1996
Topic: Drug trials: efficacy and safety
Twenty-one depressed patients with probable Alzheimer's disease (AD) were randomized to receive a 6-week treatment with clomipramine or placebo in a study with a double-blind crossover design. Main outcome measures were Hamilton Depression, Mini-Mental State (MMSE), and Functional Independence Measure (FIM) scores. Mood improved significantly on both clomipramine and placebo, but clomipramine was significantly more effective than placebo during the first 6-week treatment period. Patients started on clomipramine maintained improvement during the washout and placebo periods, whereas patients started on placebo worsened during the washout period. However, patients on clomipramine showed significantly lower MMSE scores overall than patients on placebo. No significant drug effects were found on FIM scores. Clomipramine proved to be a useful treatment of depression in patients with probable AD.
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APA 7th
Petracca, G., Tesón, A., Chemerinski, E., Leiguarda, R., & Starkstein, S. E. (1996). A double-blind placebo-controlled study of clomipramine in depressed patients with Alzheimer's disease. The Journal of neuropsychiatry and clinical neurosciences. https://doi.org/10.1176/jnp.8.3.270
Vancouver
Petracca G, Tesón A, Chemerinski E, Leiguarda R, Starkstein SE. A double-blind placebo-controlled study of clomipramine in depressed patients with Alzheimer's disease. The Journal of neuropsychiatry and clinical neurosciences. 1996. doi:10.1176/jnp.8.3.270. PMID: 8854297.
BibTeX
@article{petracca1996-8854297,
author = {Petracca, G and Tesón, A and Chemerinski, E and Leiguarda, R and Starkstein, S E},
title = {{A double-blind placebo-controlled study of clomipramine in depressed patients with Alzheimer's disease}},
journal = {The Journal of neuropsychiatry and clinical neurosciences},
year = {1996},
doi = {10.1176/jnp.8.3.270},
pmid = {8854297},
url = {https://doi.org/10.1176/jnp.8.3.270}
}
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Key findings
- Mood improved significantly on both clomipramine and placebo, but clomipramine was significantly more effective than placebo during the first 6-week treatment period.
- However, patients on clomipramine showed significantly lower MMSE scores overall than patients on placebo.
- No significant drug effects were found on FIM scores.
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Study details
- Evidence strengthHigh
How this study scored 73/100
Published in a peer-reviewed journal, and it is a randomized controlled trial. Scored zero for sample size and effect reported because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 41 of the 56 points we could judge it on, which is 73 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The Journal of neuropsychiatry and clinical neurosciences) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 11 / 12 | A randomized controlled trial (from PubMed type “Randomized Controlled Trial”) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1996 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomized / blinded | 2 / 2 | Randomized and blinded or placebo-controlled (as stated in the record) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 8854297) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 41 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 41 of the 56 points we could judge it on is 73 out of 100. |
| Total | 73 / 100 | — |
What each of these 20 components measures, and what this score is not →
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