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Clinical, neuroimaging, and pathologic features of progressive nonfluent aphasia
Turner RS, Kenyon LC, Trojanowski JQ, Gonatas N, Grossman M.. Annals of neurology, 1996-02-01
Topic: Risk, prevention and care in population studies
We report the clinical, neuroimaging, and neuropathologic features of progressive nonfluent aphasia (PNFA), a rare neurodegenerative syndrome most notable for its distinct language disturbance. Longitudinal observations of 3 patients revealed progressively telegraphic speech and writing, followed by gradual deterioration of sentence comprehension, and finally, preterminal mutism and dementia. Magnetic resonance imaging revealed cortical atrophy most pronounced in anterior regions of the left hemisphere. Functional neuroimaging demonstrated reduced cerebral activity most prominently in left frontal and temporal regions. At necropsy, microscopic pathology of brain was most consistent with the diagnosis of "dementia lacking distinctive histology" (DLDH). A review of published primary progressive aphasia cases with adequate clinical and histopathological descriptions reveals that the most common pathology underlying PNFA is DLDH. PNFA is one example of a family of clinical syndromes with similar underlying histopathology that affects different regions of the frontal lobe.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Turner, R. S., Kenyon, L. C., Trojanowski, J. Q., Gonatas, N., & Grossman, M. (1996). Clinical, neuroimaging, and pathologic features of progressive nonfluent aphasia. Annals of neurology. https://doi.org/10.1002/ana.410390205
Vancouver
Turner RS, Kenyon LC, Trojanowski JQ, Gonatas N, Grossman M. Clinical, neuroimaging, and pathologic features of progressive nonfluent aphasia. Annals of neurology. 1996. doi:10.1002/ana.410390205. PMID: 8967747.
BibTeX
@article{turner1996-8967747,
author = {Turner, R. S. and Kenyon, L. C. and Trojanowski, J. Q. and Gonatas, N. and Grossman, M.},
title = {{Clinical, neuroimaging, and pathologic features of progressive nonfluent aphasia}},
journal = {Annals of neurology},
year = {1996},
doi = {10.1002/ana.410390205},
pmid = {8967747},
url = {https://doi.org/10.1002/ana.410390205}
}
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Key findings
- Longitudinal observations of 3 patients revealed progressively telegraphic speech and writing, followed by gradual deterioration of sentence comprehension, and finally, preterminal mutism and dementia.
- Magnetic resonance imaging revealed cortical atrophy most pronounced in anterior regions of the left hemisphere.
- Functional neuroimaging demonstrated reduced cerebral activity most prominently in left frontal and temporal regions.
Why it matters
This small longitudinal study of 3 patients describes progressive nonfluent aphasia, a rare syndrome with declining speech and language, and found brain pathology most consistent with dementia lacking distinctive histology. It provides descriptive information about this syndrome but does not test any treatment, cure, or prevention for Alzheimer's disease.
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Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 59/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Annals of neurology) |
| Journal's citation record | 3 / 4 | Annals of Neurology: journal h-index 437 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1996 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 158 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.9 citations a year over 32 year(s) since 1996 |
| Impact for its field and year | 3 / 6 | Cited 5.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 16 other studies in this library |
| Still being cited | 1 / 4 | Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Murray Grossman: h-index 119 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Pennsylvania: institution h-index 1,859 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 8967747) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 59 / 100 | — |
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