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Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome
Insausti AM, Megías M, Crespo D, Cruz-Orive LM, Dierssen M, Vallina IF, Insausti R, Flórez J.. Neuroscience letters, 1998-09-01
Topic: Brain proteins, microglia and lab models
Ts65Dn mouse displays a partial triplication of chromosome 16 and is adopted as a model for Down syndrome (DS). It is known that Ts65Dn mice present memory deficiencies. In order to gain insight into the cause of these deficiencies, we studied the possibility of changes in volumes and neuronal numbers in different regions of the hippocampus (dentate gyrus, CA3, CA2 and CA1) in trisomic mice as compared to control littermates using stereological methods. The mean hippocampal volumes of Ts65Dn mice did not show significant differences as compared to controls, except in CA2 where there was a barely significant decrease. However, mean neuron number was significantly lower in Ts65Dn mice than in controls in dentate gyrus (43.7 x 10(4), CV 21%, n = 5, vs. 30.4 x 10(4), CV 18.1%, n = 4) and higher in CA3 (23.1 x 10(4), CV 18.9% vs. 33.3 x 10(4), CV 14.9%). These quantitative changes may account for the memory deficiencies observed in Ts65Dn mice.
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APA 7th
Insausti, A. M., Megías, M., Crespo, D., Cruz-Orive, L. M., Dierssen, M., Vallina, I. F., et al. (1998). Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome. Neuroscience letters. https://doi.org/10.1016/s0304-3940(98)00641-7
Vancouver
Insausti AM, Megías M, Crespo D, Cruz-Orive LM, Dierssen M, Vallina IF, et al. Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome. Neuroscience letters. 1998. doi:10.1016/s0304-3940(98)00641-7. PMID: 9792239.
BibTeX
@article{insausti1998-9792239,
author = {Insausti, A. M. and Megías, M. and Crespo, D. and Cruz-Orive, L. M. and Dierssen, M. and Vallina, I. F. and Insausti, R. and Flórez, J.},
title = {{Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome}},
journal = {Neuroscience letters},
year = {1998},
doi = {10.1016/s0304-3940(98)00641-7},
pmid = {9792239},
url = {https://doi.org/10.1016/s0304-3940(98)00641-7}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- In order to gain insight into the cause of these deficiencies, we studied the possibility of changes in volumes and neuronal numbers in different regions of the hippocampus (dentate gyrus, CA3, CA2 and CA1) in trisomic mice as compared to control littermates using stereological methods.
- The mean hippocampal volumes of Ts65Dn mice did not show significant differences as compared to controls, except in CA2 where there was a barely significant decrease.
- However, mean neuron number was significantly lower in Ts65Dn mice than in controls in dentate gyrus (43.7 x 10(4), CV 21%, n = 5, vs. 30.4 x 10(4), CV 18.1%, n = 4) and higher in CA3 (23.1 x 10(4), CV 18.9% vs. 33.3 x 10(4), CV 14.9%).
Study details
- Effect size18.1%; 18.9%; 14.9%
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 23 of the 58 points we could judge it on, which is 40 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neuroscience letters) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1998 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “mice”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 9792239) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 23 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 23 of the 58 points we could judge it on is 40 out of 100. |
| Total | 40 / 100 | — |
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