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53/100

✓ Peer-reviewed alzhub usefulness score 53 out of 100. Getting a diagnosis

Topic: Amyloid, tau and blood-test diagnosis

Results Factor analysis showed four robust and meaningful symptom clusters: factor 1-stereotypic and eating behaviour; factor 2-executive dysfunction and self care; factor 3-mood changes; factor 4-loss of social awareness. By contrast, executive dysfunction, poor self care, and restlessness showed a significant effect of disease severity only, with the more impaired patients scoring more highly. Analysis of individual symptoms showed increased rates of mental rigidity and depression in the patients with semantic dementia compared with those with fv FTD. Discriminant function analysis correctly classified 71.4% overall and 86.5% of the patients with AD.

Key findings

Results Factor analysis showed four robust and meaningful symptom clusters: factor 1-stereotypic and eating behaviour; factor 2-executive dysfunction and self care; factor 3-mood changes; factor 4-loss of social awareness.
By contrast, executive dysfunction, poor self care, and restlessness showed a significant effect of disease severity only, with the more impaired patients scoring more highly.
Analysis of individual symptoms showed increased rates of mental rigidity and depression in the patients with semantic dementia compared with those with fv FTD.
Discriminant function analysis correctly classified 71.4% overall and 86.5% of the patients with AD.

Why it matters

This study examined which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease. It is about differential diagnosis, not about treating, curing or preventing Alzheimer's disease.

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Study details

Participants33
Effect size71.4%; 86.5%
Evidence strengthLow

How this study scored 53/100

Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of neurology, neurosurgery, and psychiatry)
Journal's citation record	3 / 4	Journal of Neurology Neurosurgery & Psychiatry: journal h-index 336 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2000 — older than 20 years, still counted
Sample size	1 / 4	33 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	6 / 7	Cited 608 times (OpenAlex, 2026-10-10)
Citations per year	4 / 5	21.7 citations a year over 28 year(s) since 2000
Impact for its field and year	4 / 6	Cited 11.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	4 / 6	Cited by 32 other studies in this library
Still being cited	2 / 4	Cited 28 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Sasha Bozeat: h-index 11 (OpenAlex, whole career)
Institution's track record	1 / 3	Addenbrooke's Hospital: institution h-index 1,025 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 10896690)
Free to read	0 / 2	Behind a paywall — scores zero
Total	53 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

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APA 7th

Bozeat, S., Gregory, C. A., Ralph, M. A., & Hodges, JR. (2000). Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease? Journal of neurology, neurosurgery, and psychiatry. https://doi.org/10.1136/jnnp.69.2.178

Vancouver

Bozeat S, Gregory CA, Ralph MA, Hodges JR. Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease? Journal of neurology, neurosurgery, and psychiatry. 2000. doi:10.1136/jnnp.69.2.178. PMID: 10896690.

BibTeX

@article{bozeat2000-10896690,
  author  = {Bozeat, S. and Gregory, C. A. and Ralph, M. A. and Hodges, JR.},
  title   = {{Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease?}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2000},
  doi     = {10.1136/jnnp.69.2.178},
  pmid    = {10896690},
  url     = {https://doi.org/10.1136/jnnp.69.2.178}
}

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